Advances in understanding the regulatory mechanism of cholesterol 7α-hydroxylase

被引：25

作者：

Ge, Mao-xu ^{[1
,2
]}

Shao, Rong-guang ^{[1
,2
]}

He, Hong-wei ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, NHFPC, Key Lab Biotechnol Antibiot, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

BIOCHEMICAL PHARMACOLOGY | 2019年 / 164卷

基金：

中国国家自然科学基金;

关键词：

CYP7A1; Bile acid; microRNAs; Gut microbiome; Hypercholesterolemia; FARNESOID-X-RECEPTOR; FIBROBLAST-GROWTH-FACTOR; BILE-ACID METABOLISM; NUCLEAR FACTOR 4-ALPHA; DIFFERENTIAL REGULATION; INTRAHEPATIC CHOLESTASIS; SIGNALING PATHWAY; MESSENGER-RNA; UP-REGULATION; HUMAN CYP7A1;

D O I：

10.1016/j.bcp.2019.04.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The conversion of cholesterol to bile acids (BAs) contributes to the elimination of total cholesterol from the body. In addition, manipulating BA homeostasis by modulating cholesterol 7 alpha-hydroxylase (CYP7A1) may affect the metabolic processing of cholesterol, exerting therapeutic effects on hypercholesterolemia and cardiovascular diseases. Multiple mechanisms (such as various nuclear receptors and regulatory factors) are involved in CYP7A1 modulation. Recently, microRNAs, protein degradation pathways, and the gut microbiota have been identified to participate in these sophisticated networks. In this review, research progress on the regulatory mechanism of CYP7A1 is summarized.

引用

页码：152 / 164

页数：13

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