Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease

被引：9
作者：
Adegoke, Samuel A. [1 ,3 ]
Braga, Josefina A. P. [2 ]
Adekile, Adekunle D. [4 ]
Figueiredo, Maria S. [1 ]
机构：
[1] Univ Fed Sao Paulo, Haematol & Blood Transfus Div, Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil
[3] Obafemi Awolowo Univ, Dept Pediat & Child Hlth, PMB 013, Ife, Nigeria
[4] Kuwait Univ, Dept Paediat, Fac Med, Kuwait, Kuwait
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 04期
关键词：
fat percentage; growth; hydroxyurea; 25-hydroxyvitamin D; nutritional status; VITAMIN-D DEFICIENCY; GROWTH; ANEMIA;
D O I：
10.1097/MPH.0000000000001002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). Design: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. Results: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.11.2 vs. 19.1 +/- 9.8ng/mL, P=0.007). Conclusions: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.
引用
收藏
页码：E243 / E247
页数：5
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