Nationwide Biomonitoring of Neonicotinoid Insecticides in Breast Milk and Health Risk Assessment to Nursing Infants in the Chinese Population

被引：43

作者：

Chen, Dawei ^{[1
]}

Liu, Zhibin ^{[1
,2
]}

Barrett, Holly ^{[3
]}

Han, Jiajun ^{[3
]}

Lv, Bing ^{[1
]}

Li, Yan ^{[1
]}

Li, Jingguang ^{[1
]}

Zhao, Yunfeng ^{[1
]}

Wu, Yongning ^{[1
]}

机构：

[1] Chinese Acad Med Sci, NHC Key Lab Food Safety Risk Assessment, Res Unit 2019RU014, China Natl Ctr Food Safety Risk Assessment, Beijing 100021, Peoples R China

[2] Nanchang Inst Food & Drug Control, Nanchang Key Lab Detect & Control Food Safety, Nanchang 330096, Jiangxi, Peoples R China

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2020年 / 68卷 / 47期

基金：

国家重点研发计划;

关键词：

neonicotinoid; breast milk; risk assessment; infants; biomonitoring; ENVIRONMENTAL RISKS; EXPOSURE; METABOLITES; TOXICITY; RESIDUES;

D O I：

10.1021/acs.jafc.0c05769

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Presently, the potential health risks of neonicotinoid insecticides (neonics) are now receiving much attention, but no data regarding the exposure of infants to neonics via human breast milk intake have been reported. In this study, a nationwide survey was conducted during the period of 2017-2019, wherein 97 pooled breast milk samples were collected from 3570 lactating women of 23 provinces in China. Nationally, acetamiprid-N-desmethyl was the most predominant compound, accounting for 61.2% of the total amount of neonics, followed by imidacloprid (15.6%). The concentration of the sum of acetamiprid and its metabolite acetamiprid-N-desmethyl in breast milk was positively correlated with corresponding dietary exposure, while no statistically significant association between the other neonic levels in breast milk and dietary exposure was found. The cumulative daily intakes of neonics (9.40-249 ng kg(-1) of body weight day(-1)) were estimated for breastfed infants, indicating a minuscule risk to Chinese infants from neonic exposure via breastfeeding.

引用

页码：13906 / 13915

页数：10

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