Gait synchronization in Caenorhabditis elegans

被引:34
|
作者
Yuan, Jinzhou [1 ]
Raizen, David M. [2 ]
Bau, Haim H. [1 ]
机构
[1] Univ Penn, Dept Mech Engn & Appl Mech, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
COHERENT STRUCTURES; SPERM; LOCOMOTION; DYNAMICS; HYDRODYNAMICS; ELECTROTAXIS; COOPERATION; PATTERNS; MODEL;
D O I
10.1073/pnas.1401828111
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Collective motion is observed in swarms of swimmers of various sizes, ranging from self-propelled nanoparticles to fish. The mechanisms that govern interactions among individuals are debated, and vary from one species to another. Although the interactions among relatively large animals, such as fish, are controlled by their nervous systems, the interactions among microorganisms, which lack nervous systems, are controlled through physical and chemical pathways. Little is known, however, regarding the mechanism of collective movements in microscopic organisms with nervous systems. To attempt to remedy this, we studied collective swimming behavior in the nematode Caenorhabditis elegans, a microorganism with a compact nervous system. We evaluated the contributions of hydrodynamic forces, contact forces, and mechanosensory input to the interactions among individuals. We devised an experiment to examine pair interactions as a function of the distance between the animals and observed that gait synchronization occurred only when the animals were in close proximity, independent of genes required for mechanosensation. Our measurements and simulations indicate that steric hindrance is the dominant factor responsible for motion synchronization in C. elegans, and that hydrodynamic interactions and genotype do not play a significant role. We infer that a similar mechanism may apply to other microscopic swimming organisms and self-propelled particles.
引用
收藏
页码:6865 / 6870
页数:6
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