Allogeneic stem cell transplantation for severe aplastic anemia: Graft rejection remains a problem

被引：4
作者：
Aki, Sahika Zeynep [1 ]
Sucak, Gulsan Turkoz [1 ]
Oezkurt, Zubeyde Nur [1 ]
Yegin, Zeynep Arzu [1 ]
Yagci, Munci [1 ]
Haznedar, Rauf [1 ]
机构：
[1] Gazi Univ, Fac Med, Dept Hematol, TR-06533 Ankara, Turkey
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2009年 / 40卷 / 01期
关键词：
Severe aplastic anemia; Allogeneic stem cell transplantation; Rejection; Fludarabine; BONE-MARROW-TRANSPLANTATION; TERM-FOLLOW-UP; ANTITHYMOCYTE GLOBULIN; CONDITIONING REGIMEN; CYCLOPHOSPHAMIDE; FLUDARABINE; BLOOD; EXPERIENCE; FAILURE;
D O I：
10.1016/j.transci.2008.11.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We reviewed the outcome in 15 consecutive patients with severe aplastic anemia with a median age of 23 years who received matched sibling peripheral blood stein cell transplantation. Conditioning regimen was cyclophosphamide (Cy) + anti-thymocyte globulin (ATG). Cumulative incidence of transplant related mortality, graft failure, acute and chronic GVHD were 20%., 33%, 25%, and 8.3%, respectively. Conditioning with Cy only, resulted in higher rejection rate compared to Cy plus ATG (75%, versus 12.5%, p = 0.03). Eighty percent of patients are alive with a median follow-up of 19.5 (4.6-35.6) months. Two of the three patients who were re-transplanted with fludarabine had sustained donor chimerism. (C) 2008 Elsevier Ltd. All rights reserved.
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页码：5 / 11
页数：7
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