Cell therapy for type 1 diabetes

被引：16

作者：

Muir, K. R. ^{[1
]}

Lima, M. J. ^{[1
]}

Docherty, H. M. ^{[1
]}

Docherty, K. ^{[1
]}

机构：

[1] Univ Aberdeen, Sch Med Sci, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2014年 / 107卷 / 04期

基金：

英国惠康基金;

关键词：

CLINICAL ISLET TRANSPLANTATION; STEM-CELLS; BETA-CELLS; IN-VITRO; PANCREATIC PROGENITORS; MOUSE EMBRYOS; VIVO; TRANSDIFFERENTIATION; IMMUNOSUPPRESSION; EXPRESSION;

D O I：

10.1093/qjmed/hcu025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell therapy in the form of human islet transplantation has been a successful form of treatment for patients with type 1 diabetes for over 10 years, but is significantly limited by lack of suitable donor material. A replenishable supply of insulin-producing cells has the potential to address this problem; however to date success has been limited to a few preclinical studies. Two of the most promising strategies include differentiation of embryonic stem cells and induced pluripotent stem cells towards insulin-producing cells and transdifferentiation of acinar or other closely related cell types towards beta-cells. Here, we discuss recent progress and challenges that need to be overcome in taking cell therapy to the clinic.

引用

页码：253 / 259

页数：7

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