Determination of cocaine and heroin with their respective metabolites in human hair using gas chromatography-mass spectrometry

被引：14

作者：

Lopez, P. ^{[1
]}

Bermejo, A. M. ^{[1
]}

Tabernero, M. J. ^{[1
]}

Fernandez, P. ^{[1
]}

Alvarez, I. ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Med, Inst Legal Med, Forens Toxicol Serv, Santiago de Compostela 15782, Spain

来源：

ANALYTICAL LETTERS | 2006年 / 39卷 / 11期

关键词：

cocaine; opiates; hair; solid phase extraction; gas chromatography mass spectrometry;

D O I：

10.1080/00032710600755769

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes a gas chromatography-mass spectrometry method for the simultaneous detection of opiates, cocaine, and benzoylecgonine from human hair samples. Conditioning samples were extracted with Waters Oasis HLB (hydrophilic-lipophilic balance) cartridges. The detector response was linear for the drugs studied over the range 0.5 - 20 ng/mg. The limits of quantitation and detection were found to be acceptable. Intra- and interbatch coefficients of variation oscillated between 0.2 and 17.9%, and mean relative errors were in the range of 0.04 - 18.2%. The recoveries were higher than 66.7% in all cases. Finally, the method was applied to 20 hair samples from drug users, obtaining positive results in all cases.

引用

页码：2307 / 2316

页数：10

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