Medial vascular calcification revisited: review and perspectives

被引：573

作者：

Lanzer, Peter ^{[1
]}

Boehm, Manfred ^{[2
]}

Sorribas, Victor ^{[3
]}

Thiriet, Marc ^{[4
]}

Janzen, Jan ^{[5
]}

Zeller, Thomas ^{[6
]}

St Hilaire, Cynthia ^{[2
]}

Shanahan, Catherine ^{[7
]}

机构：

[1] Bitterfeld Wolfen gGmbH, Hlth Care Ctr Bitterfeld, Dept Internal Med, Div Cardiovasc Dis, D-06749 Bitterfeld, Germany

[2] NIH, Ctr Mol Med, Bethesda, MD 20892 USA

[3] Univ Zaragoza, Mol Toxicol Lab, Zaragoza, Spain

[4] Natl Inst Res Comp Sci & Control, Paris, France

[5] VascPath, Bern, Switzerland

[6] Univ Heart Ctr Freiburg, Bad Krozingen, Germany

[7] Kings Coll London, Div Cardiovasc, London, England

来源：

EUROPEAN HEART JOURNAL | 2014年 / 35卷 / 23期

关键词：

Vascular calcifications; Monckeberg's media sclerosis; Vascular molecular biology and genetics; Vascular function; SMOOTH-MUSCLE-CELLS; CHRONIC KIDNEY-DISEASE; CALCIUM-PHOSPHATE DEPOSITION; FETUIN-A LEVELS; MONCKEBERGS SCLEROSIS; ARTERY CALCIFICATION; PSEUDOXANTHOMA ELASTICUM; ATHEROSCLEROTIC LESIONS; NONINVASIVE EVALUATION; EXTRACELLULAR CALCIUM;

D O I：

10.1093/eurheartj/ehu163

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.

引用

页码：1515 / U24

页数：14

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