Determination of naproxen in human plasma by GC-MS

被引：17

作者：

Yilmaz, Bilal ^{[1
]}

Sahin, Huseyin ^{[2
]}

Erdem, Ali Fuat ^{[3
]}

机构：

[1] Ataturk Univ, Fac Pharm, Dept Analyt Chem, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Dept Emergency Med, Fac Med, Erzurum, Turkey

[3] Sakarya Univ, Dept Anesthesiol & Reanimat, Fac Med, Sakarya, Turkey

来源：

JOURNAL OF SEPARATION SCIENCE | 2014年 / 37卷 / 08期

关键词：

Ibuprofen; Liquid-liquid extraction; Naproxen; Pharmacokinetics; Validation; PERFORMANCE LIQUID-CHROMATOGRAPHY; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MASS-SPECTROMETRY; HUMAN URINE; BIOLOGICAL SAMPLES; HPLC METHOD; KETOPROFEN; METABOLITE; DESMETHYLNAPROXEN; MICROEXTRACTION;

D O I：

10.1002/jssc.201301105

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes a GC-MS method for the determination of naproxen in human plasma. Naproxen and internal standard ibuprofen were extracted from plasma using a liquid-liquid extraction method. Derivatization was carried out using N-methyl-N-(trimethylsilyl)trifluoroacetamide. The calibration curve was linear between the concentration range of 0.10-5.0 g/mL. Intra- and interday precision values for naproxen in plasma were <5.14, and accuracy (relative error) was better than 4.67%. The extraction recoveries of naproxen from human plasma were between 93.0 and 98.9%. The LOD and LOQ of naproxen were 0.03 and 0.10 g/mL, respectively. Also, this assay was applied to determine the pharmacokinetic parameters of naproxen in six healthy Turkish volunteers who had been given 220 mg naproxen.

引用

页码：997 / 1003

页数：7

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