Determination of naproxen in human plasma by GC-MS

被引：17

作者：

Yilmaz, Bilal ^{[1
]}

Sahin, Huseyin ^{[2
]}

Erdem, Ali Fuat ^{[3
]}

机构：

[1] Ataturk Univ, Fac Pharm, Dept Analyt Chem, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Dept Emergency Med, Fac Med, Erzurum, Turkey

[3] Sakarya Univ, Dept Anesthesiol & Reanimat, Fac Med, Sakarya, Turkey

来源：

JOURNAL OF SEPARATION SCIENCE | 2014年 / 37卷 / 08期

关键词：

Ibuprofen; Liquid-liquid extraction; Naproxen; Pharmacokinetics; Validation; PERFORMANCE LIQUID-CHROMATOGRAPHY; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MASS-SPECTROMETRY; HUMAN URINE; BIOLOGICAL SAMPLES; HPLC METHOD; KETOPROFEN; METABOLITE; DESMETHYLNAPROXEN; MICROEXTRACTION;

D O I：

10.1002/jssc.201301105

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes a GC-MS method for the determination of naproxen in human plasma. Naproxen and internal standard ibuprofen were extracted from plasma using a liquid-liquid extraction method. Derivatization was carried out using N-methyl-N-(trimethylsilyl)trifluoroacetamide. The calibration curve was linear between the concentration range of 0.10-5.0 g/mL. Intra- and interday precision values for naproxen in plasma were <5.14, and accuracy (relative error) was better than 4.67%. The extraction recoveries of naproxen from human plasma were between 93.0 and 98.9%. The LOD and LOQ of naproxen were 0.03 and 0.10 g/mL, respectively. Also, this assay was applied to determine the pharmacokinetic parameters of naproxen in six healthy Turkish volunteers who had been given 220 mg naproxen.

引用

页码：997 / 1003

页数：7

共 50 条

[41] Determination of aminorex in human urine samples by GC-MS after use of levamisole [J].

Bertol, Elisabetta ;

Mari, Francesco ;

Di Milia, Maria Grazia ;

Politi, Lucia ;

Furlanetto, Sandra ;

Karch, Steven B. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2011, 55 (05) :1186-1189

[42] Determination of 66 pesticide residues in livestock products using QuEChERS and GC-MS/MS [J].

Kang, Hye Soon ;

Kim, MeeKyung ;

Kim, Eun Jeong ;

Choe, Won-Jo .

FOOD SCIENCE AND BIOTECHNOLOGY, 2020, 29 (11) :1573-1586

[43] Determination of atractylon in rat plasma by a GC-MS method and its application to a pharmacokinetic study [J].

Han Yan ;

Yuanyuan Sun ;

Yuying Ma ;

Bin Ji ;

Xiaohong Hou ;

Zhiguo Yu ;

Yunli Zhao .

Journal of Pharmaceutical Analysis, 2015, 5 (05) :327-331

[44] Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides [J].

Ubhayasekera, Sarojini J. K. A. ;

Staaf, Johan ;

Forslund, Anders ;

Bergsten, Peter ;

Bergquist, Jonas .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2013, 405 (06) :1929-1935

[45] Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma [J].

Sakaguchi, Yohei ;

Yoshida, Hideyuki ;

Hayama, Tadashi ;

Yoshitake, Makoto ;

Itoyama, Miki ;

Todoroki, Kenichiro ;

Yamaguchi, Masatoshi ;

Nohta, Hitoshi .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2011, 55 (01) :176-180

[46] Simultaneous GC-MS determination of nicotine and cotinine in plasma for the pharmacokinetic characterization of nicotine in rats [J].

Jung, BH ;

Chung, BC ;

Chung, SJ ;

Lee, MH ;

Shim, CK .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 20 (1-2) :195-202

[47] Synovial fluid as an alternative specimen for quantification of drugs of abuse by GC-MS [J].

Petrochilou, Evangelia ;

Athanaselis, Sotiris ;

Nikolaou, Panagiota ;

Papadodima, Stavroula ;

Panderi, Irene ;

Spiliopoulou, Chara ;

Papoutsis, Ioannis .

FORENSIC TOXICOLOGY, 2019, 37 (02) :496-503

[48] Quantitation of neonicotinoid metabolites in human urine using GC-MS [J].

Nomura, Hiroshi ;

Ueyama, Jun ;

Kondo, Takaaki ;

Saito, Isao ;

Murata, Katsuyuki ;

Iwata, Toyoto ;

Wakusawa, Shinya ;

Kamijima, Michihiro .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2013, 941 :109-115

[49] Determination and Pharmacokinetics of Glucoraphanin in Rat Plasma by UPLC-MS/MS [J].

Liu, Zezheng ;

Liu, Huamin ;

Wu, Yazhen ;

Xu, Xiaoxin ;

Ma, Jianshe .

LATIN AMERICAN JOURNAL OF PHARMACY, 2020, 39 (06) :1116-1121

[50] Development and validation of an LC-ESI-MS/MS method for the simultaneous quantification of naproxen and sumatriptan in human plasma: application to a pharmacokinetic study [J].

Bretas, Juliana Machado ;

Cesar, Isabela Costa ;

Bretas, Camila Machado ;

Teixeira, Leonardo de Souza ;

Bellorio, Karini Bruno ;

Mundim, Iram Moreira ;

Pianetti, Gerson Antonio .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 408 (15) :3981-3992

← 1 2 3 4 5 →