Role of identified RNA N6-methyladenosine methylation in liver

被引：30

作者：

Xu, Kechen ^{[1
]}

Sun, Yuchao ^{[3
]}

Sheng, Baixiang ^{[3
]}

Zheng, Yiwen ^{[4
]}

Wu, Xiaoli ^{[3
]}

Xu, Keyang ^{[2
]}

机构：

[1] Wuyi First Peoples Hosp, Clin Lab Ctr, Wuyi 321200, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Clin Med Sch 4, Hangzhou 310053, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 4, Sch Med, Yiwu 322000, Zhejiang, Peoples R China

[4] Hangzhou Med Coll, Hangzhou 310053, Zhejiang, Peoples R China

来源：

ANALYTICAL BIOCHEMISTRY | 2019年 / 578卷

关键词：

N6-methyladenosine; Methylation; Messenger RNA; Noncoding RNA; Liver; HEPATIC LIPID-METABOLISM; STEM-LIKE CELLS; MESSENGER-RNA; FAT MASS; ADENOSYLHOMOCYSTEINE HYDROLASE; REGULATES ADIPOGENESIS; S-ADENOSYLHOMOCYSTEINE; NUCLEAR-RNA; N-6-METHYLADENOSINE; OBESITY;

D O I：

10.1016/j.ab.2019.05.005

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

N6-Methyladenosine (m(6)A) is the most abundant and important internal modification site of RNA methylation in viruses and eukaryotic. m(6)A RNA methylation plays key roles in the regulation of post-transcriptional gene expression, including messenger RNA (mRNA), microRNA (miRNA) and long noncoding RNA (IncRNA). And m(6)A methylation regulates the various aspects of RNA metabolism, including structure, maturation, stability, splicing, export, translation and decay. Liver is a vital metabolic and digestive organ in the pathophysiological processes. Recent studies suggested that m(6)A RNA modification highly regulates hepatic function and development of liver diseases. Here, we aim to summarize the biological and clinical significance of m(6)A modification in hepatic growth and hepatic disease including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), and liver cancer.

引用

页码：45 / 50

页数：6

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