Application and design of esterase-responsive nanoparticles for cancer therapy

被引：146
作者：
Dong, Haonan [1 ]
Pang, Long [1 ]
Cong, Hailin [1 ,2 ]
Shen, Youqing [1 ,3 ,4 ]
Yu, Bing [1 ,2 ]
机构：
[1] Qingdao Univ, Coll Chem & Chem Engn, Coll Mat Sci & Engn, Inst Biomed Mat & Engn, Qingdao, Shandong, Peoples R China
[2] Qingdao Univ, State Key Lab Biofibers & Ecotext, Qingdao, Shandong, Peoples R China
[3] Zhejiang Univ, Ctr Bionanoengn, Minist Educ, Key Lab Biomass Chem Engn, Hangzhou, Zhejiang, Peoples R China
[4] Zhejiang Univ, Dept Chem & Biol Engn, Hangzhou, Zhejiang, Peoples R China
来源：
DRUG DELIVERY | 2019年 / 26卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Esterase-responsive nanoparticles; drug carriers; gene therapy; photosensitizers; fluorescent imaging; G-PEI MICELLES; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; CO-DELIVERY; 5-AMINOLEVULINIC ACID; POLYMERIC MICELLES; IN-VITRO; PORPHYRIN SYNTHESIS; PROTOPORPHYRIN-IX; SYSTEMIC DELIVERY;
D O I：
10.1080/10717544.2019.1588424
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the specific structure and physicochemical properties of tumors have attracted more and more attention of researchers. Esterase-responsive nanoparticle system is widely used due to the overexpressed esterase in tumor cells. For a rational designed esterase-responsive nanoparticle, ester bonds and nanoparticle structures are the key characters. In this review, we overviewed the design of esterase-responsive nanoparticles, including ester bonds design and nano-structure design, and analyzed the fitness of each design for different application. In the end, the outlook of esterase-responsive nanoparticle is looking forward.
引用
收藏
页码：416 / 432
页数：17
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