Belimumab treatment in rhupus: A case report with severe skin involvement

被引：6

作者：

Castillo Dayer, Paloma Valentina ^{[1
]}

Lozano Rivas, Nuria ^{[1
]}

Martinez Ferrin, Javier Jose ^{[1
]}

Victoria Martinez, Ana Mercedes ^{[2
]}

Sanchez-Pedreno Guillen, Paloma ^{[2
]}

Marras Fernandez-Cid, Carlos ^{[1
]}

机构：

[1] Hosp Clin Univ Virgen Arrixaca, Rheumatol Dept, Murcia, Spain

[2] Hosp Clin Univ Virgen Arrixaca, Dermatol Dept, Murcia, Spain

来源：

DERMATOLOGIC THERAPY | 2019年 / 32卷 / 05期

关键词：

belimumab; rheumatoid arthritis; rhupus; systemic lupus erythematosus; EFFICACY; RITUXIMAB; ARTHRITIS; PATIENT; SAFETY;

D O I：

10.1111/dth.13056

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Patients with rhupus characteristically exhibit symmetric polyarthritis and clinical manifestations suggestive of systemic lupus erythematosus (malar rash, photosensitivity, hematological manifestations, serositis, and/or skin involvement) and positive anti-dsDNA. Treatment is unclear and it can include disease-modifying rheumatic drugs like hydroxyl chloroquine, or methotrexate or, in refractory cases, rituximab or abatacept. We report a case of 31-year-old female who present with rhupus with skin acute lesions treated with belimumab. This is the first case of rhupus treated with this drug described in the literature.

引用

页数：4

共 13 条

[1] Efficacy and tolerability of rituximab in patients with rhupus [J].

Andrade-Ortega, Lilia ;

Irazoque-Palazuelos, Fedra ;

Munoz-Lopez, Sandra ;

Rosales-Don Pablo, Victor Manuel .

REUMATOLOGIA CLINICA, 2013, 9 (04) :201-205

[2]

Araújo F, 2013, ACTA REUMATOL PORT, V38, P290

[3]

Danion F, 2017, RMD OPEN, V3, DOI 10.1136/rmdopen-2017-000555

[4] Chronic arthritis in systemic lupus erythematosus: distinct features in 336 paediatric and 1830 adult patients [J].

Gormezano, Natali W. S. ;

Silva, Clovis A. ;

Aikawa, Nadia E. ;

Barros, Diego L. ;

da Silva, Mariana A. ;

Otsuzi, Carini I. ;

Kozu, Katia ;

Seguro, Luciana Parente ;

Pereira, Rosa M. R. ;

Bonfa, Eloisa .

CLINICAL RHEUMATOLOGY, 2016, 35 (01) :227-231

[5] Efficacy of Abatacept for Arthritis in Patients with an Overlap Syndrome between Rheumatoid Arthritis and Systemic Lupus Erythematosus [J].

Ikeda, Kei ;

Sanayama, Yoshie ;

Makita, Sohei ;

Hosokawa, Junichi ;

Yamagata, Mieko ;

Nakagomi, Daiki ;

Takabayashi, Katsuhiko ;

Nakajima, Hiroshi .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2013,

[6] Belimumab - an anti-BLyS human monoclonal antibody for rheumatoid arthritis [J].

Jin, Xingzhong ;

Ding, Changhai .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (02) :315-322

[7] Clinical Analysis of 56 Patients With Rhupus Syndrome: Manifestations and Comparisons With Systemic Lupus Erythematosus A Retrospective Case-Control Study [J].

Li, Jing ;

Wu, Honghua ;

Huang, Xinxiang ;

Xu, Dong ;

Zheng, Wenjie ;

Zhao, Yan ;

Liu, Wanli ;

Zeng, Xiaofeng .

MEDICINE, 2014, 93 (10) :e49

[8] Belimumab in the treatment of systemic lupus erythematous: An evidence based review of its place in therapy [J].

Marcondes, Frederico ;

Scheinberg, Morton .

AUTOIMMUNITY REVIEWS, 2018, 17 (02) :103-107

[9]

Seo SR, 2011, CLIN EXP RHEUMATOL, V29, P708

[10] Rhupus; unusual presentations [J].

Shovman, Ora ;

Langevitz, Pnina ;

Shoenfeld, Yehuda .

CLINICAL RHEUMATOLOGY, 2015, 34 (12) :2041-2046

← 1 2 →