Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection

被引：76

作者：

Day, Cheryl L.

Kiepiela, Photini

Leslie, Alasdair J.

van der Stok, Mary

Nair, Kriebashne

Ismail, Nasreen

Honeyborne, Isobella

Crawford, Hayley

Coovadia, Hoosen M.

Goulder, Philip J. R.

Walker, Bruce D.

Klenerman, Paul

机构：

[1] Nuffield Dept Med, Oxford OX1 3SY, England

[2] Univ KwaZulu Natal, Doris Duke Med Res Inst, HIV Pathogenesis Programme, ZA-4013 Durban, South Africa

[3] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Div AIDS, Boston, MA 02115 USA

[5] Howard Hughes Med Inst, Chevy Chase, MD 20185 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.01754-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naive HIV type 1 clade C virus-infected persons in KwaZuJu Natal, South Africa. In terms of effector functions of proliferation, cytokine production, and degranulation, only proliferation showed a significant correlation with viral load. This robust inverse relationship provides an important functional correlate of viral control relevant to both vaccine design and evaluation.

引用

页码：434 / 438

页数：5