Customizing poly(lactic-co-glycolic acid) particles for biomedical applications

被引：229
作者：
Swider, Edyta [1 ]
Koshkina, Olga [1 ]
Tel, Jurjen [1 ,4 ]
Cruz, Luis J. [2 ]
de Vries, I. Jolanda M. [1 ,3 ]
Srinivas, Mangala [1 ]
机构：
[1] Radboud Inst Mol Life Sci, Dept Tumor Immunol, Nijmegen, Netherlands
[2] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands
[3] Radboud, Dept Med Oncol, Nijmegen, Netherlands
[4] Eindhoven Univ Technol, Lab Immunoengn, Dept Biomed Engn, Eindhoven, Netherlands
来源：
ACTA BIOMATERIALIA | 2018年 / 73卷
基金：
欧洲研究理事会;
关键词：
Poly(lactic-co-glycolic acid); Particles; Drug delivery; Theranostics; Imaging; PLGA-BASED NANOPARTICLES; CO-GLYCOLIC ACID; DRUG-DELIVERY; DENDRITIC CELLS; BIODEGRADABLE NANOPARTICLES; POLYMERIC NANOPARTICLES; PEG NANOPARTICLES; IN-VITRO; POLY(LACTIDE-CO-GLYCOLIDE); MICROPARTICLES;
D O I：
10.1016/j.actbio.2018.04.006
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Nano- and microparticles have increasingly widespread applications in nanomedicine, ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles are the most widely-applied type of particles due to their biocompatibility and biodegradability. Here, we discuss the preparation of PLGA particles, and various modifications to tailor particles for applications in biological systems. We highlight new preparation approaches, including microfluidics and PRINT method, and modifications of PLGA particles resulting in novel or responsive properties, such as Janus or upconversion particles. Finally, we describe how the preparation methods can- and should-be adapted to tailor the properties of particles for the desired biomedical application. Our aim is to enable researchers who work with PLGA particles to better appreciate the effects of the selected preparation procedure on the final properties of the particles and its biological implications. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd.
引用
收藏
页码：38 / 51
页数：14
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