Brain changes after spinal cord injury, a quantitative meta-analysis and review

被引：59

作者：

Dahlberg, Linda Solstrand ^{[1
,2
,3
]}

Becerra, Lino ^{[1
,2
,3
,4
,5
,6
,7
]}

Borsook, David ^{[1
,2
,3
,4
,5
,6
,7
]}

Linnman, Clas ^{[1
,2
,3
,8
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[4] Harvard Med Sch, Boston Childrens Hosp, Ctr Pain & Brain, Boston, MA USA

[5] Harvard Med Sch, MGH, Boston, MA USA

[6] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA

[7] Harvard Med Sch, Charlestown, MA USA

[8] Harvard Med Sch, Spaulding Rehabil Hosp, Charlestown, MA USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2018年 / 90卷

关键词：

Spinal cord injury; Neuroimaging; Meta-analysis; Plasticity; Cortical reorganization; MRI; OF-THE-ART; MAGNETIC-RESONANCE-SPECTROSCOPY; PRIMARY SENSORIMOTOR CORTEX; HUMAN MOTOR CORTEX; NEUROPATHIC PAIN; FUNCTIONAL REORGANIZATION; CORTICAL REORGANIZATION; SOMATOSENSORY CORTEX; BIOCHEMICAL-CHANGES; COGNITIVE DEFICITS;

D O I：

10.1016/j.neubiorev.2018.04.018

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Spinal Cord Injuries (SCI) lead to alterations in brain structure and brain function by direct effects of nerve damage, by secondary mechanisms, and also by longer term injury consequences such as paralysis and neuropathic pain. Here, we review neuroimaging studies of patients with traumatic spinal cord injuries, perform a quantitative meta-analysis of motor and motor imagery studies, summarize structural studies, evidence of cortical reorganization, and provide an overview of diffusion and spectroscopy studies. The meta-analysis showed significantly altered motor cortex, as well as cerebellar and parietal lobe changes, and qualitatively consistent reports of alterations in somatosensory brain structure, cortical reorganization, white matter diffusion and thalamic metabolites. Larger samples in combination with standardized imaging protocols and data sharing will further our understanding of brain changes after SCI and help in defining short and long-term changes in brain systems in SCI patients. Such data would provide a basis for clinical trials, treatment outcomes, and guide novel interventions.

引用

页码：272 / 293

页数：22

共 141 条

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