G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition

被引：61

作者：

Sahakyan, Aleksandr B. ^{[1
,2
]}

Murat, Pierre ^{[1
,2
]}

Mayer, Clemens ^{[1
,2
]}

Balasubramanian, Shankar ^{[1
,2
,3
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge, England

[2] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England

[3] Univ Cambridge, Sch Clin Med, Cambridge, England

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2017年 / 24卷 / 03期

基金：

欧洲研究理事会;

关键词：

TRANSPOSABLE ELEMENTS; L1; RETROTRANSPOSITION; SMALL-MOLECULE;

D O I：

10.1038/nsmb.3367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3' untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.

引用

页码：243 / +

页数：7

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