Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells

被引：180
作者：
Huang, Ying
Sadee, Wolfgang
机构：
[1] US FDA, Natl Ctr Toxicol Res, Div Pharmacogenom & Mol Epidemiol, Jefferson, AR 72079 USA
[2] Ohio State Univ, Program Pharmacogenom, Dept Pharmacol, Ctr Comprehens Canc,Coll Med & Publ Hlth, Columbus, OH 43210 USA
来源：
CANCER LETTERS | 2006年 / 239卷 / 02期
关键词：
membrane transporter; ABC transporter; SLC transporter; ion channel; chemosensitivity; chemoresistance;
D O I：
10.1016/j.canlet.2005.07.032
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Membrane transporters play important roles in mediating chemosensitivity and -resistance of tumor cells. ABC transporters, such as ABCB1/MDR1, ABCC1/MRP1 and ABCG2/BCRP, are frequently associated with decreased cellular accumulation of anticancer drugs and multidrug resistance of tumors. SLC transporters, such as folate, nucleoside, and amino acid transporters, commonly increase chemosensitivity by mediating the cellular uptake of hydrophilic drugs. Ion channels and pumps variably affect sensitivity to anticancer therapy by modulating viability of tumor cells. A pharmacogenomic approach, using correlations between drug potency and transporter gene expression in multiple cancer cell lines, has shown promise for identifying potential drug-transporter relationships and predicting anticancer drug response, in an effort to optimize chemotherapy for individual patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：168 / 182
页数：15
相关论文
共 100 条
[1]  
Allikmets R, 1998, CANCER RES, V58, P5337
[2]   P-glycoprotein: from genomics to mechanism [J].
Ambudkar, SV ;
Kimchi-Sarfaty, C ;
Sauna, ZE ;
Gottesman, MM .
ONCOGENE, 2003, 22 (47) :7468-7485
[3]   The equilibrative nucleoside transporter family, SLC29 [J].
Baldwin, SA ;
Beal, PR ;
Yao, SYM ;
King, AE ;
Cass, CE ;
Young, JD .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2004, 447 (05) :735-743
[4]   Nucleoside transporters: molecular biology and implications for therapeutic development [J].
Baldwin, SA ;
Mackay, JR ;
Cass, CE ;
Young, JD .
MOLECULAR MEDICINE TODAY, 1999, 5 (05) :216-224
[5]   Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9 [J].
Bhattacharjee, H ;
Carbrey, J ;
Rosen, BP ;
Mukhopadhyay, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 322 (03) :836-841
[6]   Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation [J].
Boonstra, R ;
Timmer-Bosscha, H ;
van Echten-Arends, J ;
van der Kolk, DM ;
van den Berg, A ;
de Jong, B ;
Tew, KD ;
Poppema, S ;
de Vries, EGE .
BRITISH JOURNAL OF CANCER, 2004, 90 (12) :2411-2417
[7]   ABC transporters in lipid transport [J].
Borst, P ;
Zelcer, N ;
van Helvoort, A .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1486 (01) :128-144
[8]   Anticancer multidrug resistance mediated by MRP1: Recent advances in the discovery of reversal agents [J].
Boumendjel, A ;
Baubichon-Cortay, H ;
Trompier, D ;
Perrotton, T ;
Di Pietro, A .
MEDICINAL RESEARCH REVIEWS, 2005, 25 (04) :453-472
[9]   Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases [J].
Bowman, EJ ;
Gustafson, KR ;
Bowman, BJ ;
Boyd, MR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (45) :44147-44152
[10]   Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump [J].
Burger, H ;
van Tol, H ;
Boersma, AWM ;
Brok, M ;
Wiemer, EAC ;
Stoler, G ;
Nooter, K .
BLOOD, 2004, 104 (09) :2940-2942
12345678910