Separation of phenothiazines in aqueous and non-aqueous capillary electrophoresis

被引：28
|
作者：
Wang, RY [1 ]
Lu, XN [1 ]
Xin, HJ [1 ]
Wu, MJ [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Natl Analyt Res Ctr Electrochem & Spect, Changchun 130022, Jilin, Peoples R China
来源：
CHROMATOGRAPHIA | 2000年 / 51卷 / 1-2期
关键词：
capillary electrophoresis; non-aqueous media; drug separation; phenothiazines;
D O I：
10.1007/BF02490692
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Four phenothiazines, promethazine, dioxypromethazine, chlorpromazine, and trifluoperazine have been separated by capillary electrophoresis using N, N, -dimethylformamide (DMF) as separation medium with UV absorbance detection. High voltage and concentrated buffer were used with small current and low electroosmosis. Good resolution and high column efficiency were obtained. Separation selectivity in DMI; was different from that in water because of the different solvation interactions. The influence of buffer composition on separation selectivities and electroosmosis were also studied.
引用
收藏
页码：29 / 36
页数：8
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