HER-2/neu Overexpression as a Predictor for the Transition from In situ to Invasive Breast Cancer

被引:102
作者
Roses, Robert E. [1 ]
Paulson, E. Carter [1 ]
Sharma, Anupama [1 ]
Schueller, Jeanne E. [1 ]
Nisenbaum, Harvey [2 ]
Weinstein, Susan [2 ]
Fox, Kevin R. [3 ]
Zhang, Paul J. [4 ]
Czerniecki, Brian J. [1 ]
机构
[1] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
关键词
LYMPH-NODE BIOPSY; EXPRESSION; CELLS;
D O I
10.1158/1055-9965.EPI-08-1101
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The clinical implications of HER-2/neu (HER2) expression in ductal carcinoma in situ (DCIS) lesions have yet to be clearly elucidated; this despite the more frequent expression of HER2 in high-grade DCIS lesions compared with invasive cancers. We hypothesized that HER2 overexpression in DCIS is associated with more rapid progression to invasive disease. Immunohistochemical staining for estrogen receptor, progesterone receptor, and HER2 was done on DCIS specimens. Univariate analysis and a multivariate logistic regression were done to determine whether estrogen receptor, progesterone receptor, or HER2 status, comedo necrosis, nuclear grade, lesion size, or patient age predicted the presence of associated invasive disease in patients with DCIS. Invasive foci were found in association with HER2 overexpressing DCIS at a higher frequency than with DCIS that did not overexpress HER2. Although high nuclear grade, large lesion size, and HER2 overexpression were all associated with the presence of invasive disease on univariate analysis, HER2 was the only significant predictor for the presence of invasive disease after multivariate adjustment (odds ratio, 6.4; P = 0.01). These data indicate that HER2 overexpression in DCIS lesions predicts the presence of invasive foci in patients with DCIS and suggest that targeting of HER2 in an early disease setting may forestall or prevent disease progression. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1386-9)
引用
收藏
页码:1386 / 1389
页数:4
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