Bioconcentration and tissue distribution of shorter and longer chain perfluoroalkyl acids (PFAAs) in zebrafish (Danio rerio): Effects of perfluorinated carbon chain length and zebrafish protein content

被引：60
作者：
Wen, Wu [1 ]
Xia, Xinghui [1 ]
Zhou, Dong [1 ]
Wang, Haotian [1 ]
Zhai, Yawei [1 ]
Lin, Hui [1 ]
Chen, Jian [1 ]
Hu, Diexuan [1 ]
机构：
[1] Beijing Normal Univ, Sch Environm, State Key Lab Water Environm Simulat, Beijing 100875, Peoples R China
来源：
ENVIRONMENTAL POLLUTION | 2019年 / 249卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Shorter chain PFAAs; Bioaccumulation; Protein content; Zebrafish; Perfluoroalkyl substances (PFASs); ALKYL ACIDS; HALOGENATED CHEMICALS; ADULT ZEBRAFISH; PEARL RIVER; SOUTH CHINA; SUBSTANCES; BIOACCUMULATION; EXPOSURE; WATER; SEDIMENT;
D O I：
10.1016/j.envpol.2019.03.003
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Perfluoroalkyl acids (PFAAs) are a class of emerging pollutants. However, the bioconcentration and tissue distribution of shorter chain PFAAs in aquatic animals are not well understood. Here, we investigated the effects of perfluorinated carbon chain length of PFAAs and protein content of tissues on the bioconcentration and tissue distribution of both shorter chain PFAAs (linear C-F = 3-6) and longer chain PFAAs (linear C-F = 7-11) in zebrafish. The results showed that the uptake rate constants (k(u)) and the bioconcentration factors (BCFss) of the shorter chain PFAAs (0.042-32 L.kg(ww)(-)(1).d(-1) and 0.12-24 L.kg(ww)(-1) respectively) in tissues were significantly lower than those of the longer chain PFAAs (2.8 -1.4 x 10(3) L.kg(ww)(-1).d(-1) and 9.7-1.9 x 10(4) L.kg(ww)(-1) respectively). Moreover, the concentrations of both longer and shorter chain PFAAs were lowest in the muscle where the protein content was lowest, and they were highest in blood and liver where the protein content was highest among tissues except brain. The protein content of the brain was higher than that of the liver but the concentrations of PFAAs in the brain were significantly lower than those in the liver because of the blood-brain barrier. In addition, the ovary/blood and brain/blood ratios of concentrations for the shorter chain PFAAs were lower than those for the longer chain PFAAs. Generally, both log k(u) and log BCFss showed a significantly positive correlation with either perfluorinated carbon number of PFAAs or protein content of tissues (P < 0.05). Further nonlinear surface fitting revealed that the effect of perfluorinated carbon number was more significant than protein content on the PFAA bioconcentration in zebrafish tissues. These results suggest that there are differences in the bioconcentration and tissue distribution between longer and shorter chain PFAAs and the shorter chain PFAAs seem to be safe compared with the longer chain PFAAs. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：277 / 285
页数：9
相关论文
共 55 条
[1]   Total body burden and tissue distribution of polyfluorinated compounds in harbor seals (Phoca vitulina) from the German Bight [J].
Ahrens, Lutz ;
Siebert, Ursula ;
Ebinghaus, Ralf .
MARINE POLLUTION BULLETIN, 2009, 58 (04) :520-525
[2]   Perfluorinated Compounds in the Environment and the Blood of Residents Living near Fluorochemical Plants in Fuxin, China [J].
Bao, Jia ;
Liu, Wei ;
Liu, Li ;
Jin, Yihe ;
Dai, Jiayin ;
Ran, Xiaorong ;
Zhang, Zhixu ;
Tsuda, Shuji .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2011, 45 (19) :8075-8080
[3]   Bioavailability and bioconcentration potential of perfluoroalkyl-phosphinic and -phosphonic acids in zebrafish (Danio rerio): Comparison to perfluorocarboxylates and perfluorosulfonates [J].
Chen, Fangfang ;
Gong, Zhiyuan ;
Kelly, Barry C. .
SCIENCE OF THE TOTAL ENVIRONMENT, 2016, 568 :33-41
[4]   Multimedia Distribution and Transfer of Per- and Polyfluoroalkyl Substances (PFASs) Surrounding Two Fluorochemical Manufacturing Facilities in Fuxin, China [J].
Chen, Hao ;
Yao, Yiming ;
Zhao, Zhen ;
Wang, Yu ;
Wang, Qj ;
Ren, Chao ;
Wang, Bin ;
Sun, Hongwen ;
Alder, Alfredo C. ;
Kannan, Kurunthachalam .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 52 (15) :8263-8271
[5]   Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring [J].
Chen, Jiangfei ;
Das, Siba R. ;
La Du, Jane ;
Corvi, Margaret M. ;
Bai, Chenglian ;
Chen, Yuanhong ;
Liu, Xiaojuan ;
Zhu, Guonian ;
Tanguay, Robert L. ;
Dong, Qiaoxiang ;
Huang, Changjiang .
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2013, 32 (01) :201-206
[6]   Predicting Relative Protein Affinity of Novel Per- and Polyfluoroalkyl Substances (PFASs) by An Efficient Molecular Dynamics Approach [J].
Cheng, Weixiao ;
Ng, Carla A. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 52 (14) :7972-7980
[7]   Are PFCAs bioaccumulative? A critical review and comparison with regulatory lipophilic compounds [J].
Conder, Jason M. ;
Hoke, Robert A. ;
De Wolf, Watze ;
Russell, Mark H. ;
Buck, Robert C. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (04) :995-1003
[8]  
DeWitt JC, 2015, MOLEC INTEGR TOXICOL, P1, DOI 10.1007/978-3-319-15518-0
[9]   Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice [J].
Gannon, Shawn A. ;
Johnson, Terry ;
Nabb, Diane L. ;
Serex, Tessa L. ;
Buck, Robert C. ;
Loveless, Scott E. .
TOXICOLOGY, 2011, 283 (01) :55-62
[10]   Acute mixture toxicity of halogenated chemicals and their next generation counterparts on zebrafish embryos [J].
Godfrey, Amy ;
Abdel-moneim, Ahmed ;
Sepulveda, Maria S. .
CHEMOSPHERE, 2017, 181 :710-712
123456