Hemicrania continua responds to cyclooxygenase-2 inhibitors

被引：44

作者：

Peres, MFP ^{[1
]}

Silberstein, SD ^{[1
]}

机构：

[1] Thomas Jefferson Univ Hosp, Dept Neurol, Jefferson Headache Ctr, Philadelphia, PA 19107 USA

来源：

HEADACHE | 2002年 / 42卷 / 06期

关键词：

hemicrania continua; celecoxib; rofecoxib; indomethacin; COX-2; inhibitors;

D O I：

10.1046/j.1526-4610.2002.02131.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background.-Hemicrania continua is a primary headache disorder defined by its absolute responsiveness to indomethacin. We report the treatment response to two cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, in a series of patients with hemicrania continua. Methods.-Fourteen patients were treated, 9 with rofecoxib and 5 with celecoxib. Results.-Three patients in each group had a complete response to treatment. Conclusion.-The cyclooxygenase-2 inhibitors may represent an alternative to indomethacin in the treatment of hemicrania continua. Their mechanism of action for this potential indication is unknown.

引用

页码：530 / 531

页数：2

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