γ-Hydroxybutyric Acid-Induced Electrographic Seizures

被引：3
作者：
Cheung, Joseph [1 ]
Lucey, Brendan P. [1 ]
Duntley, Stephen P. [1 ]
Darken, Rachel S. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
来源：
JOURNAL OF CLINICAL SLEEP MEDICINE | 2014年 / 10卷 / 07期
关键词：
seizure; narcolepsy; pharmacology;
D O I：
10.5664/jcsm.3882
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We describe a case of absence-like electrographic seizures during NREM sleep in a patient who was taking sodium oxybate, a sodium salt of gamma-hydroxybutyric acid (GHB). An overnight full montage electroencephalography (EEG) study revealed numerous frontally predominant rhythmic 1.5-2 Hz sharp waves and spike-wave activity during stage N2 and N3 sleep at the peak dose time for sodium oxybate, resembling atypical absence-like electrographic seizures. The patient was later weaned off sodium oxybate, and a repeat study did not show any such electrographic seizures. Absence-like seizures induced by GHB had previously been described in experimental animal models. We present the first reported human case of absence-like electrographic seizure associated with sodium oxybate.
引用
收藏
页码：811 / 812
页数：2
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