γ-Hydroxybutyric Acid-Induced Electrographic Seizures

被引：3

作者：

Cheung, Joseph ^{[1
]}

Lucey, Brendan P. ^{[1
]}

Duntley, Stephen P. ^{[1
]}

Darken, Rachel S. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

来源：

JOURNAL OF CLINICAL SLEEP MEDICINE | 2014年 / 10卷 / 07期

关键词：

seizure; narcolepsy; pharmacology;

D O I：

10.5664/jcsm.3882

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a case of absence-like electrographic seizures during NREM sleep in a patient who was taking sodium oxybate, a sodium salt of gamma-hydroxybutyric acid (GHB). An overnight full montage electroencephalography (EEG) study revealed numerous frontally predominant rhythmic 1.5-2 Hz sharp waves and spike-wave activity during stage N2 and N3 sleep at the peak dose time for sodium oxybate, resembling atypical absence-like electrographic seizures. The patient was later weaned off sodium oxybate, and a repeat study did not show any such electrographic seizures. Absence-like seizures induced by GHB had previously been described in experimental animal models. We present the first reported human case of absence-like electrographic seizure associated with sodium oxybate.

引用

页码：811 / 812

页数：2

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