Status of PI3K/Akt/mTOR Pathway Inhibitors in Lymphoma

被引：89

作者：

Westin, Jason R. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Lymphoma & Myeloma, Houston, TX 77030 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2014年 / 14卷 / 05期

关键词：

Akt; Lymphoma; mTor; PI3K; Review; Signalling; Targeted; Therapy; B-CELL; PHOSPHOINOSITIDE; 3-KINASE; PHASE-I; EMBRYONIC LETHALITY; CATALYTIC SUBUNIT; PI3K PATHWAY; SOLID TUMORS; PTEN LOSS; CANCER; ACTIVATION;

D O I：

10.1016/j.clml.2014.01.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The phosphatidylinositol-3-kinase (PI3K) pathway is well known to regulate a wide variety of essential cellular functions, including glucose metabolism, translational regulation of protein synthesis, cell proliferation, apoptosis, and survival. Aberrations in the PI3K pathway are among the most frequently observed in cancer, and include amplifications, rearrangements, mutations, and loss of regulators. As a net result of these anomalies, the PI3K pathway is activated in many malignancies, including in Hodgkin and non-Hodgkin lymphomas, and yields a competitive growth and survival advantage, increased metastatic ability, and resistance to conventional therapy. Numerous inhibitors targeting various nodes in the PI3K pathway are undergoing clinical development, and their current status in lymphoma will be the focus of this review.

引用

页码：335 / 342

页数：8

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