Secondary Metabolites Isolated From Streptomyces sp. MJM3055 and Their Cytotoxicity Against Jurkat Cells

被引：2

作者：

Qiu, Yinda ^{[1
,2
]}

Yoo, Hee Min ^{[3
]}

Cho, Namki ^{[1
]}

Yan, Pengcheng ^{[2
]}

Liu, Zhiguo ^{[2
]}

Cheng, Jinhua ^{[4
]}

Suh, Joo-Won ^{[4
]}

机构：

[1] Chonnam Natl Univ, Coll Pharm, Gwangju, South Korea

[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China

[3] Korea Res Inst Stand & Sci KRISS, Biometrol Grp, Microbiol Anal Team, Daejeon, South Korea

[4] Myongji Univ, Ctr Nutraceut & Pharmaceut Mat, Myongjiro 116, Yongin 17058, Gyeonggi, South Korea

来源：

NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

Streptomyces; secondary metabolites; streptenol derivative; jurkat T cells; cytotoxic;

D O I：

10.1177/1934578X20977591

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bacteria of the genus Streptomyces are used in multiple applications in the medical field owing to their ability to generate large quantities of secondary metabolites. Chromatographic purification of Streptomyes sp. MJM3055 led to the isolation of 1 new streptenol derivative, 1-O-acetylstreptenol A (2), along with (3E,8E)-1-hydrox ydeca-3,8-dien-5-one (1), streptenol A (3), cyclo-(L-Ile-L-Pro) (4), streptazolin (5), and 7-O-acetylstreptazolin (6). The structures were elucidated by interpretation of combined mass spectrometry, circular dichroism, and 2-dimensional nuclear magnetic resonance spectroscopic data. Among these isolated compounds, compound 1 exhibited strong cytotoxic effects against Jurkat T cells.

引用

页数：6

共 50 条

[21] Streptomyces musisoli sp. nov., an actinomycete isolated from soil
Duangupama, Thitikorn
Intaraudom, Chakapong
Pittayakhajonwut, Pattama
Suriyachadkun, Chanwit
Tadtong, Sarin
Sirirote, Pramote
Tanasupawat, Somboon
Thawai, Chitti
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2021, 71 (07)
[22] Polyene Carboxylic Acids from a Streptomyces sp. Isolated from Tibet Soil
Zhang, Manyu
Ren, Jinwei
Luo, Yuanming
Xie, Weidong
Li, Erwei
MOLECULES, 2023, 28 (06):
[23] Secondary Metabolites from Streptomyces sp CSDX076 for the First Time
Qian, S. Y.
Shao, M. Y.
Li, Y. Z.
Cheng, G. G.
Yue, C. W.
WEST INDIAN MEDICAL JOURNAL, 2018, 67 (02) : 110 - 113
[24] Characterization and mapping of secondary metabolites of Streptomyces sp. from caatinga by desorption electrospray ionization mass spectrometry (DESI–MS)
Júlia Pereira Rodrigues
Shamina Saiyara Prova
Luiz Alberto Beraldo Moraes
Demian Rocha Ifa
Analytical and Bioanalytical Chemistry, 2018, 410 : 7135 - 7144
[25] Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus
P. W. Yang
M. G. Li
J. Y. Zhao
M. Z. Zhu
H. Shang
J. R. Li
X. L. Cui
R. Huang
M. L. Wen
Folia Microbiologica, 2010, 55 : 10 - 16
[26] Pluramycinone Metabolites from Streptomyces sp. SA0215, Isolated from the Saudi Red Sea Sediments with Antimicrobial and Cytotoxic Activity
Ghandourah, M.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY, 2025, : 110 - 116
[27] Bioactive Secondary Metabolites from the Locally Isolated Terrestrial Fungus, Penicillium sp. SAM16-EGY
Ghareeb, Mosad A.
Flamed, Manal M.
Saad, Amal M.
Abdel-Aziz, Mohamed S.
Flamed, Ahmed A.
Refahy, Laila A.
PHARMACOGNOSY RESEARCH, 2019, 11 (02): : 162 - 170
[28] Secondary Metabolites from Usnea sp. and an Evaluation of Their Cytotoxic and Antibacterial Activities
Agustini, Dewi Meliati
Riga, Riga
Hermawati, Elvira
Saputra, Budi
BAGHDAD SCIENCE JOURNAL, 2025, 22 (01) : 103 - 109
[29] Secondary Metabolites from the Mangrove-derived Fungus Trichoderma sp.
Zi, Guangrong
Shi, Ying
Hong, Kui
Liu, Ling
NATURAL PRODUCTS JOURNAL, 2024,
[30] Secondary metabolites from the[italic] Actinomadura[/italic] sp. and their cytotoxic activity
He, Jiang-Bo
Wang, Ying
Zhang, Gao-Hong
Wang, Ji-Ai
Chen, Yi-Shu
Jia, Jing
Lv, Xiao-man
Ren, Fu-Cai
Chen, Bing
Cao, Yan-Ru
FITOTERAPIA, 2024, 173

← 1 2 3 4 5 →