Secondary Metabolites Isolated From Streptomyces sp. MJM3055 and Their Cytotoxicity Against Jurkat Cells

被引：2
|
作者：
Qiu, Yinda [1 ,2 ]
Yoo, Hee Min [3 ]
Cho, Namki [1 ]
Yan, Pengcheng [2 ]
Liu, Zhiguo [2 ]
Cheng, Jinhua [4 ]
Suh, Joo-Won [4 ]
机构：
[1] Chonnam Natl Univ, Coll Pharm, Gwangju, South Korea
[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China
[3] Korea Res Inst Stand & Sci KRISS, Biometrol Grp, Microbiol Anal Team, Daejeon, South Korea
[4] Myongji Univ, Ctr Nutraceut & Pharmaceut Mat, Myongjiro 116, Yongin 17058, Gyeonggi, South Korea
来源：
NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
Streptomyces; secondary metabolites; streptenol derivative; jurkat T cells; cytotoxic;
D O I：
10.1177/1934578X20977591
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bacteria of the genus Streptomyces are used in multiple applications in the medical field owing to their ability to generate large quantities of secondary metabolites. Chromatographic purification of Streptomyes sp. MJM3055 led to the isolation of 1 new streptenol derivative, 1-O-acetylstreptenol A (2), along with (3E,8E)-1-hydrox ydeca-3,8-dien-5-one (1), streptenol A (3), cyclo-(L-Ile-L-Pro) (4), streptazolin (5), and 7-O-acetylstreptazolin (6). The structures were elucidated by interpretation of combined mass spectrometry, circular dichroism, and 2-dimensional nuclear magnetic resonance spectroscopic data. Among these isolated compounds, compound 1 exhibited strong cytotoxic effects against Jurkat T cells.
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页数：6
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