Prognostic Impact of Hepatectomy for Patients with Non-hepatitis B, Non-hepatitis C Hepatocellular Carcinoma

被引：0
作者：
Ochiai, Toshiya [1 ,2 ]
Ogino, Shinpei [1 ,2 ]
Ishimoto, Takeshi [1 ,2 ]
Toma, Atsushi [1 ,2 ]
Yamamoto, Yusuke [1 ]
Morimura, Ryo [1 ]
Ikoma, Hisashi [1 ]
Otsuji, Eigo [1 ]
机构：
[1] Kyoto Prefectural Univ Med, Dept Surg, Med Ctr N, Div Digest Surg, Kyoto 6292261, Japan
[2] Kyoto Prefectural Univ Med, Dept Surg, Med Ctr N, Kyoto 6292261, Japan
来源：
ANTICANCER RESEARCH | 2014年 / 34卷 / 08期
关键词：
Hepatocellular carcinoma; virus; surgery; non-hepatitis B non-hepatitis C; cirrhosis; FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; CLINICAL CHARACTERISTICS; CRYPTOGENIC CIRRHOSIS; NATURAL-HISTORY; INTRAHEPATIC RECURRENCE; ALCOHOLIC CIRRHOSIS; VIRUS INTEGRATION; VIRAL-INFECTION; RISK-FACTORS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Back ground/Aim: The purpose of the present study was to clarify the clinicopathological features of non-hepatitis B and -C (NBNC) hepatocellular carcinoma (HCC), the incidence of which has been increasing. Patients and Methods: Two hundred and eighty-four patients with HCC were classified into three groups according to viral hepatitis status, namely NBNC, hepatitis B, and hepatitis C. We compared the three groups and studied related risk factors. Results: Patients without cirrhosis who had increased number of platelets and diabetes mellitus, and a serum alpha-feto-protein (AFP) level <100 ng/dl were more common in the NBNC group. The cumulative survival and disease-free survival were better in the NBNC group than in the other groups. The tumor size and hepatitis B or C viral status were found to be independent risk factors of disease-free survival and the presence of multiple lesions was the only independent risk factor of survival. Conclusion: Close follow-up of NBNC liver cirrhosis and early detection of NBNC-HCC can improve the prognosis after surgery.
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页码：4399 / 4410
页数：12
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