Chloroquine Inhibits Colon Cancer Cell Growth In Vitro and Tumor Growth In Vivo via Induction of Apoptosis

被引：81

作者：

Zheng, Yuzhu ^{[1
]}

Zhao, Ying-Lan ^{[1
]}

Deng, Xiaoqiang ^{[1
]}

Yang, Shengyong ^{[1
]}

Mao, Yongqiu ^{[1
]}

Li, Zhengguang ^{[1
]}

Jiang, Peidu ^{[1
]}

Zhao, Xia ^{[2
]}

Wei, Yuquan ^{[1
]}

机构：

[1] Sichuan Univ, W China Med Sch, W China Hosp, State Key Lab Biotherapy & Canc Ctr, Chengdu 610041, Peoples R China

[2] Sichuan Univ, W China Med Sch, W China Hosp 2, Dept Gynecol & Obstet, Chengdu 610041, Peoples R China

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 03期

关键词：

Chloroquine; Colon cancer; Cell apoptosis; TNF-ALPHA; DEATH; INVOLVEMENT; QUERCETIN; CARCINOMA; PATHWAYS; IL-6;

D O I：

10.1080/07357900802427927

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study was to investigate the anticancer effect of chloroquine on proliferation of mouse colon cancer cell line CT26 in vivo and in vitro and the possible mechanism. We found that chloroquine inhibited CT26 proliferation by concentration- and time-dependent manner. This effect was associated with apoptosis induction and decreased level of phosphorylated p42/44 mitogen-activated protein kinase and phosphorylated Akt. The in vivo study showed chloroquine-reduced tumor volume and prolonged survival time in CT26-bearing mice. These observations indicated chloroquine could inhibit CT26 proliferation by inducing apoptosis both in vitro and in vivo, providing its chemotherapeutic potential of human cancers.

引用

页码：286 / 292

页数：7

共 41 条

[1] Signalling pathways of the TNF superfamily: A double-edged sword [J].

Aggarwal, BB .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (09) :745-756

[2]

Amaravadi RK, 2005, BLOOD, V106, p681A

[3]

BEDOYA V, 1970, CANCER RES, V30, P1262

[4]

Cal C., 2003, Current Medicinal Chemistry - Anti-Cancer Agents, V3, P77, DOI 10.2174/1568011033353443

[5]

Chau Ian, 2003, Clin Colorectal Cancer, V3, P19, DOI 10.3816/CCC.2003.n.009

[6]

CHRIS JN, 2004, ONCOGENE, V23, P2797

[7] Clinical studies of apoptosis and proliferation in breast cancer [J].

Dowsett, M ;

Archer, A ;

Assersohn, L ;

Gregory, RK ;

Ellis, PA ;

Salter, J ;

Chang, J ;

Mainwaring, P ;

Boeddinghaus, I ;

Johnston, SRD ;

Powles, TJ ;

Smith, IE .

[8] Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells [J].

Edwards, LA ;

Verreault, M ;

Thiessen, B ;

Dragowska, WH ;

Hu, YP ;

Yeung, JHF ;

Dedhar, S ;

Bally, MB .

MOLECULAR CANCER THERAPEUTICS, 2006, 5 (03) :645-654

[9] Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells [J].

Fan, CD ;

Wang, WW ;

Zhao, BX ;

Zhang, SL ;

Miao, JY .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (09) :3218-3222

[10] Cytoplasmic vacuolation, adaptation and cell death: A view on new perspectives and features [J].

Henics, T ;

Wheatley, DN .

BIOLOGY OF THE CELL, 1999, 91 (07) :485-498

← 1 2 3 4 5 →