The battlefield of perforin/granzyme cell death pathways

被引：54

作者：

Hoves, Sabine ^{[1
]}

Trapani, Joseph A. ^{[1
,2
]}

Voskoboinik, Ilia ^{[1
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

[3] Univ Melbourne, Dept Genet, Melbourne, Vic 3010, Australia

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 87卷 / 02期

关键词：

cytotoxic lymphocyte; natural killer cell; familial hemophagocytic lymphohistiocytosis; PORE-FORMING PROTEIN; CD8(+) T-CELLS; GRANULE-MEDIATED APOPTOSIS; CULTURED MAST-CELLS; HUMAN GRANZYME-B; IN-VIVO; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HUMAN KERATINOCYTES; GENE-EXPRESSION; TARGET-CELLS;

D O I：

10.1189/jlb.0909608

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A pore-forming protein, PRF, and serine proteases, Grz, are key effector molecules of CL. These toxins are stored within secretory granules, which exocytose their contents in response to immune synapse formation between the CL and virus-infected or transformed target cell. There, PRF and Grz synergize to induce various apoptotic death pathways and to maintain immune homeostasis. Mechanistic aspects of the synergy and apoptotic mechanisms are still not fully understood, and the current review will address some of the hotly debated controversies in the field. J. Leukoc. Biol. 87: 237-243; 2010.

引用

页码：237 / 243

页数：7

共 99 条

[1] Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition [J].

Andrade, Felipe ;

Fellows, Edward ;

Jenne, Dieter E. ;

Rosen, Antony ;

Young, C. S. H. .

EMBO JOURNAL, 2007, 26 (08) :2148-2157

[2] Defective regulatory and effector T cell functions in patients with FOXP3 mutations [J].

Bacchetta, Rosa ;

Passerini, Laura ;

Gambineri, Eleonora ;

Dai, Minyue ;

Allan, Sarah E. ;

Perroni, Lucia ;

Dagna-Bricarelli, Franca ;

Sartirana, Claudia ;

Matthes-Martins, Susanne ;

Lawitschka, Anita ;

Azzari, Chiara ;

Ziegler, Steven F. ;

Levings, Megan K. ;

Roncarolo, Maria Grazia .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (06) :1713-1722

[3] A proteomic analysis of lysosomal integral membrane proteins reveals the diverse composition of the organelle [J].

Bagshaw, RD ;

Mahuran, DJ ;

Callahan, JW .

MOLECULAR & CELLULAR PROTEOMICS, 2005, 4 (02) :133-143

[4] The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly [J].

Baran, Katherine ;

Dunstone, Michelle ;

Chia, Jenny ;

Ciccone, Annette ;

Browne, Kylie A. ;

Clarke, Christopher J. P. ;

Lukoyanova, Natalya ;

Saibil, Helen ;

Whisstock, James C. ;

Voskoboinik, Ilia ;

Trapani, Joseph A. .

IMMUNITY, 2009, 30 (05) :684-695

[5]

Berthou C, 1997, J IMMUNOL, V159, P5293

[6] NK cell protease granzyme M targets α-tubulin and disorganizes the microtubule network [J].

Bovenschen, Niels ;

de Koning, Pieter J. A. ;

Quadir, Razi ;

Broekhuizen, Roel ;

Damen, J. Mirjam A. ;

Froelich, Christopher J. ;

Slijper, Monique ;

Kummer, J. Alain .

JOURNAL OF IMMUNOLOGY, 2008, 180 (12) :8184-8191

[7] IL-21 induces the functional maturation of murine NK cells [J].

Brady, J ;

Hayakawa, Y ;

Smyth, MJ ;

Nutt, SL .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2048-2058

[8] Granzyme K: a novel mediator in acute airway inflammation [J].

Bratke, K. ;

Klug, A. ;

Julius, P. ;

Kuepper, M. ;

Lommatzsch, M. ;

Sparmann, G. ;

Luttmann, W. ;

Virchow, J. C. .

THORAX, 2008, 63 (11) :1006-1011

[9]

Browne KA, 1999, MOL CELL BIOL, V19, P8604

[10] Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin [J].

Buzza, MS ;

Zamurs, L ;

Sun, JR ;

Bird, CH ;

Smith, AI ;

Trapani, JA ;

Froelich, CJ ;

Nice, EC ;

Bird, PI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (25) :23549-23558

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