Ex-vivo lung perfusion: the model for the organ reconditioning hub

被引:27
|
作者
Yeung, Jonathan C. [1 ]
Cypel, Marcelo [1 ]
Keshavjee, Shaf [1 ]
机构
[1] Univ Toronto, Toronto Gen Hosp, Div Thorac Surg, Toronto Lung Transplant Program, Toronto, ON, Canada
关键词
ex-vivo lung perfusion; lung preservation; lung transplantation; organ procurement center; TRANSPLANTATION; HEART; DONOR;
D O I
10.1097/MOT.0000000000000404
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Purpose of review Lung evaluation and reconditioning by ex-vivo lung perfusion (EVLP) is becoming increasingly established. We review strategies for broader implementation of this technology to transplant centers worldwide. Recent findings The organ reconditioning hub model is a viable strategy for disseminating EVLP to small and large transplant centers given the well tolerated prolongation of preservation time afforded by EVLP. Regulatory and process issues remain hurdles to be overcome. Summary EVLP demonstrates promise to increase lung utilization. Organ reconditioning hubs appear to be an efficient method of delivering this promise to all transplant centers, not necessarily only the largest ones. Organ allocation processes will need to adapt to this new paradigm of organ preservation
引用
收藏
页码:287 / 289
页数:3
相关论文
共 50 条
  • [1] Optimization of Organ Perfusion in a preclinical ex-vivo Lung Perfusion Model
    Knoblich, I
    Linge, H.
    Wiese-Rischke, C.
    Padmanabhan, S.
    Kulvait, V
    Rose, G.
    Walles, T.
    PNEUMOLOGIE, 2022, 76 (02): : 119 - 120
  • [2] Ex-vivo lung perfusion
    Garijo, Jacobo Moreno
    Roscoe, Andrew
    CURRENT OPINION IN ANESTHESIOLOGY, 2020, 33 (01) : 50 - 54
  • [3] Ex-vivo Lung Perfusion
    Wiegmann, Bettina
    Haverich, Axel
    TRANSFUSIONSMEDIZIN, 2018, 8 (04) : 220 - 225
  • [4] Ex-vivo lung perfusion
    Van Raemdonck, Dirk
    Neyrinck, Arne
    Cypel, Marcelo
    Keshavjee, Shaf
    TRANSPLANT INTERNATIONAL, 2015, 28 (06) : 643 - 656
  • [5] Ex-vivo lung perfusion
    Sanchez, Pablo G.
    D'Ovidio, Frank
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2012, 17 (05) : 490 - 495
  • [6] Development of a Donor Lung Discard Score to Prompt Assessment for Ex-Vivo Lung Perfusion Reconditioning
    Legeai, C.
    Picard, C.
    Pison, C.
    Sage, E.
    Mercier, O.
    Huot, O.
    Dorent, R.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2017, 36 (04): : S54 - S54
  • [7] Pre- and Reconditioning of DCD Donor Lungs on Ex-Vivo Lung Perfusion by Methylprednisolone
    Martens, A.
    Van Raemdonck, D. E.
    Vanaudenaerde, B. M.
    Verleden, S. E.
    Verleden, G. M.
    Vos, R.
    Neyrinck, A. P.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2016, 35 (04): : S143 - S143
  • [8] Extracorporeal lung perfusion (ex-vivo lung perfusion)
    Cypel, Marcelo
    Keshavjee, Shaf
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2016, 21 (03) : 329 - 335
  • [9] Extrarenal Ex-Vivo Perfusion for Organ Preservation
    Guarrera, James V.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 : 47 - 48
  • [10] Ex-vivo lung perfusion therapies: do they add value to organ donation?
    Lyengar, Amit
    Schiazza, Alexis
    Cantu, Edward, III
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2022, 27 (03) : 204 - 210