Biomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex

被引：21

作者：

Li, Quan-Li ^{[1
]}

Chen, Zhi-Qing

Darvell, Brian W.

Zeng, Quan

Li, Gang

Ou, Guo-Min

Wu, Ming-Yue

机构：

[1] Anhui Med Univ, Hefei, Peoples R China

[2] Sichuan Univ, W China Stomatol Coll, Chengdu 610064, Peoples R China

[3] Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China

[4] Kunming Med Coll, Kunming, Peoples R China

来源：

MATERIALS LETTERS | 2006年 / 60卷 / 29-30期

基金：

国家高技术研究发展计划(863计划);

关键词：

chitosan; phosphorylated chitosan; polyclectrolyte complex; crystal growth; encapsulation for drug release; nanocomposites;

D O I：

10.1016/j.matlet.2006.03.046

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan (PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation) solution containing calcium and phosphate ions (Ca2+ : 6 mM, Ca/P = 1.67) was added into a PCS (polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopic carbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PEC by controlled crystal growth. The resulting composite material, PEC-HA, has a complicated porous structure that is expected to have high biocompatibility and that may be of use as materials for bone replacement and a carrier for controlled-release therapeutic agents. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：3533 / 3536

页数：4

共 14 条

[1] Biomimetic mineralization and bioactivity of phosphorylated chitosan [J].