Antioxidant metal oxide nanozymes: role in cellular redox homeostasis and therapeutics

被引:7
作者
Singh, Namrata [1 ]
机构
[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India
关键词
2020 IUPAC-Solvay Award; cancer; catalase; endothelial dysfunction; glutathione peroxidase; hydrogen peroxide; nanozymes; neurodegenerative diseases; oxidative stress; reactive oxygen species; superoxide; superoxide dismutase; CYTOCHROME-C-OXIDASE; OXYGEN SPECIES ROS; OXIDATIVE STRESS; NITRIC-OXIDE; GLUTATHIONE-PEROXIDASE; BIOMEDICAL APPLICATIONS; ARTIFICIAL ENZYMES; MITOCHONDRIAL DYSFUNCTION; PLATINUM NANOPARTICLES; CERIA NANOPARTICLES;
D O I
10.1515/pac-2020-0802
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanomaterials with enzyme-like activity, generally referred to as 'nanozymes', find myriad potential in various biomedical fields. More importantly, the nanoparticles that can functionally mimic the activity of cellular antioxidant enzymes attract tremendous interest owing to their possible therapeutic candidature in oxidative stress-mediated disorders. Oxidative stress culminating due to excess reactive oxygen species (ROS) level and dysregulated cellular antioxidant machinery is implicated in the development and progression of various pathophysiological disorders such as cancer, diabetes, cardiovascular and neurodegenerative diseases. Moreover, the optimum essentiality of ROS due to its pivotal role in cell signaling evokes the requirement of novel artificial antioxidant enzymes that can circumvent the detrimental effects of enhanced ROS levels without perturbing the basal redox status of cells. In recent years, the fast emanating artificial enzymes, i.e. nanozymes with antioxidant enzyme-like activity, has made tremendous progress with their broad applications in therapeutics, diagnostic medicine, bio-sensing, and immunoassay. Among various antioxidant nanoparticles reported till-date, the metal oxide nanozymes have emerged as the most efficient and successful candidates in mimicking the activity of first-line defense antioxidant enzymes, i.e. superoxide dismutase, catalase, and glutathione peroxidase. This review intends to exclusively highlight the development of representative metal oxide-based antioxidant nanozymes capable of maintaining the cellular redox homeostasis and their potential therapeutic significance.
引用
收藏
页码:187 / 205
页数:19
相关论文
共 171 条
  • [1] Artificial DNA cutters for DNA manipulation and genome engineering
    Aiba, Yuichiro
    Sumaoka, Jun
    Komiyama, Makoto
    [J]. CHEMICAL SOCIETY REVIEWS, 2011, 40 (12) : 5657 - 5668
  • [2] A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties
    Ali, SS
    Hardt, JI
    Quick, KL
    Kim-Han, JS
    Erlanger, BF
    Huang, TT
    Epstein, CJ
    Dugan, LL
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (08) : 1191 - 1202
  • [3] Downregulation of Tumor Growth and Invasion by Redox-Active Nanoparticles
    Alili, Lirija
    Sack, Maren
    von Montfort, Claudia
    Giri, Shailendra
    Das, Soumen
    Carroll, Kate S.
    Zanger, Klaus
    Seal, Sudipta
    Brenneisen, Peter
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2013, 19 (08) : 765 - 778
  • [4] Arthur JR, 2000, CELL MOL LIFE SCI, V57, P1825
  • [5] A Review of the Catalytic Mechanism of Human Manganese Superoxide Dismutase
    Azadmanesh, Jahaun
    Borgstahl, Gloria E. O.
    [J]. ANTIOXIDANTS, 2018, 7 (02)
  • [6] A repertoire of biomedical applications of noble metal nanoparticles
    Azharuddin, Mohammad
    Zhu, Geyunjian H.
    Das, Debapratim
    Ozgur, Erdogan
    Uzun, Lokman
    Turner, Anthony P. F.
    Patra, Hirak K.
    [J]. CHEMICAL COMMUNICATIONS, 2019, 55 (49) : 6964 - 6996
  • [7] Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles
    Bao, Qunqun
    Hu, Ping
    Xu, Yingying
    Cheng, Tiansheng
    Wei, Chenyang
    Pan, Limin
    Shi, Jianlin
    [J]. ACS NANO, 2018, 12 (07) : 6794 - 6805
  • [8] Neurodegenerative diseases and oxidative stress
    Barnham, KJ
    Masters, CL
    Bush, AI
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (03) : 205 - 214
  • [9] Antioxidant Activity of Sulfur and Selenium: A Review of Reactive Oxygen Species Scavenging, Glutathione Peroxidase, and Metal-Binding Antioxidant Mechanisms
    Battin, Erin E.
    Brumaghim, Julia L.
    [J]. CELL BIOCHEMISTRY AND BIOPHYSICS, 2009, 55 (01) : 1 - 23
  • [10] ROLE OF OXIDATIVE STRESS IN DEVELOPMENT OF COMPLICATIONS IN DIABETES
    BAYNES, JW
    [J]. DIABETES, 1991, 40 (04) : 405 - 412