Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors

被引：15

作者：

Basu, Sujay ^{[1
]}

Prathipati, Philip ^{[1
]}

Thorat, Sachin ^{[1
]}

Ansari, Shariq ^{[1
]}

Patel, Meena ^{[1
]}

Jain, Vaibhav ^{[1
]}

Jinugu, Ramana R. ^{[1
]}

Niranjan, Sanjay ^{[1
]}

De, Siddhartha ^{[1
]}

Reddy, Satyanarayana ^{[1
]}

机构：

[1] Advinus Therapeut Ltd, Drug Discovery Facil, MIDC, Quantum Towers,Plot 9,Phase 1, Pune 411057, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 01期

关键词：

Protein tyrosine phosphatase 1B; Pharmacophore; Permeability; Hydrophobic; Oxadiazole; PTP1B INHIBITORS; COMPETITIVE INHIBITOR; PTP-1B INHIBITORS; DRUG DESIGN; DISCOVERY; POTENT; OBESITY;

D O I：

10.1016/j.bmc.2016.10.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel amino-carboxylic based pyrazole as protein tyrosine phosphatase 1B (PTP1B) inhibitors were designed on the basis of structure-based pharmacophore model and molecular docking. Compounds containing different hydrophobic tail (1,2-diphenyl ethanone, oxdiadizole and dibenzyl amines) were synthesized and evaluated in PTP1B enzymatic assay. Structure-activity relationship based optimization resulted in identification of several potent, metabolically stable and cell permeable PTP1B inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.

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收藏

页码：67 / 74

页数：8

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