Asymmetric cyclopropanation catalyzed by C2-symmetric bis-(ephedrine)-Cu(II) complexes

被引：6
作者：
Gao, JA [1 ]
Zhong, SH
机构：
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA
[2] Tianjin Univ, Coll Chem Engn & Technol, Tianjin 300072, Peoples R China
来源：
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2003年 / 191卷 / 01期
关键词：
cyclopropanation; chiral ligand; asymmetric; ephedrine;
D O I：
10.1016/S1381-1169(02)00326-6
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The asymmetric cyclopropanation of styrene with alkyl diazoacetate was performed with a series of Cu(II) complexes of novel chiral ligands, which were derived from substitution of 1,3-dibromopropane, 1,2-dibromoethane, alpha,alpha'-dibromo-m-xylene and 2,6-bis(bromomethyl)pyridine with 1R, 2S-(-)-ephedrine. These prepared catalysts shown to be highly active in the enantioselective cyclopropanation with ee higher than 89% under the optimal conditions. (C) 2002 Elsevier Science B.V. All rights reserved.
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收藏
页码：23 / 27
页数：5
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