Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro

被引：51

作者：

Chen, Quan Cheng ^{[1
,2
]}

Zhang, Wei Yun ^{[1
]}

Jin, Wenyi ^{[1
]}

Lee, Ik Soo ^{[1
]}

Min, Byung-Sun ^{[3
]}

Jung, Hyun-Ju ^{[4
]}

Na, Minkyun ^{[5
]}

Lee, SangMyung ^{[6
]}

Bae, KiHwan ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Xiamen Univ, Inst Biomed Res, Xiamen, Peoples R China

[3] Catholic Univ Daegu, Coll Pharm, Gyeongbuk, South Korea

[4] Wonkwang Univ, Dept Oriental Pharm, Jeonbuk, South Korea

[5] Yeungnam Univ, Coll Pharm, Gyeongbuk, South Korea

[6] KT&G Cent Res Inst, Taejon, South Korea

来源：

PLANTA MEDICA | 2010年 / 76卷 / 01期

关键词：

Sophora japonica; Leguminosae; flavonoids; isoflavonoids; glucose uptake; diabetes mellitus; ISOLATED RAT ADIPOCYTES; DIABETES-MELLITUS; CELLS; TRANSLOCATION; CONSTITUENTS; TRANSPORTER; QUERCETIN; MYRICETIN; JAPONICA; INHIBIT;

D O I：

10.1055/s-0029-1185944

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Glucose uptake assay-guided fractionations on the methanol extract of Sophorae Flos led to the isolation of the flavonoids rutin (1), narcissin (2), quercetin (3), tamarixetin (4), and kaempferol (5) and the isoflavonoids cajanin (6), genistein (7), orobol (8), and pratensein (9). Among them, 1, 4, 5, 6, 8, and 9 significantly improved basal glucose uptake in HepG2 cells. Their improving effects were concentration dependent. Compounds 4, 5, 6, and 9 exhibited effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. However, 2, 3, and 7 did not show any improving effects. Stimulating glucose uptake into peripheral cells may be responsible for reducing the level of blood glucose in the circulation. Therefore, these findings demonstrate a potential to develop these flavonoids and isoflavonoids as hypoglycemic drugs.

引用

页码：79 / 81

页数：3

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