Roles of LncRNAs in Viral Infections

被引：80
作者：
Liu, Weiwei [1 ]
Ding, Chan [1 ]
机构：
[1] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Avian Infect Dept, Shanghai, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2017年 / 7卷
关键词：
long non-coding RNAs; virus infection; cellular lncRNAs; virus-encoded lncRNAs; cell-virus interaction; LONG NONCODING RNA; VIRUS-ENCODED RNAS; HUMAN CYTOMEGALOVIRUS; NUCLEOTIDE-SEQUENCE; ANTIVIRAL RESPONSES; PARKINSONS-DISEASE; IMMUNE-RESPONSE; GENE-EXPRESSION; SUBGENOMIC RNA; RIG-I;
D O I：
10.3389/fcimb.2017.00205
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Many proteins and signaling pathways participate in anti-viral host responses. Long non-coding RNAs (lncRNAs), a subset of non-coding RNAs greater than 200 nucleotides in length, have been recently described as critical regulators in viral infections. Accumulating research indicates that lncRNAs are important in the development and progression of infectious diseases. LncRNAs are not only involved in anti-viral responses, but in many different virus-host interactions, some of which may be beneficial to the virus. Here we review the current knowledge regarding host and viral lncRNAs and their roles in viral infections. In addition, the potential of using lncRNAs as diagnostic biomarkers is discussed.
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页数：10
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