Radical cyclisation of amino aldehydes leading to hydroxy pyrrolidines and piperidines

被引：18

作者：

Parsons, AF

Pettifer, RM

机构：

[1] Department of Chemistry, University of York, Heslington, York

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 33期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)01316-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclisation of amino aldehydes using Bu3SnH in boiling benzene is reported. The reaction proceeds via addition of a tributyltin radical to the aldehyde forming an O-stannyl ketyl and radical cyclisation onto electron poor or rich double bonds gives rise to hydroxy pyrrolidines and piperidines. (C) 1997 Elsevier Science Ltd.

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页码：5907 / 5910

页数：4

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