Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes

被引：5

作者：

Bew, Sean P. ^{[1
]}

Brimage, Rebecca A. ^{[1
]}

Hughes, David L. ^{[1
]}

Legentil, Laurent ^{[1
]}

Sharma, Sunil V. ^{[1
]}

Wilson, Martin A. ^{[1
]}

机构：

[1] Univ E Anglia, Sch Chem Sci & Pharm, Norwich NR4 7TJ, Norfolk, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 07期

关键词：

MICHAELIS-ARBUZOV REARRANGEMENT; COORDINATION CHEMISTRY; ALKENES; LIGAND;

D O I：

10.1021/jo062114k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Graphic An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported

引用

页码：2655 / 2658

页数：4

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