Autologous and allogeneic stem cell transplantation in multiple myeloma

被引：16

作者：

Goldschmidt, H ^{[1
]}

Egerer, G ^{[1
]}

Ho, AD ^{[1
]}

机构：

[1] Univ Heidelberg, Dept Internal Med 5, Med Klin & Poliklin 5, D-69115 Heidelberg, Germany

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / Suppl 2期

关键词：

high-dose therapy; autologous transplantation; allogeneic transplantation;

D O I：

10.1038/sj.bmt.1702348

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Multiple myeloma is still an incurable disease. The standard conventional chemotherapy comprises melphalan and prednisone (MP). Combination chemotherapy regimens could not improve the median survival of 36 months observed with MP, In the French IFM90 study, HD therapy with TBI plus melphalan 140 mg/m(2) was shown to prolong overall survival and progression-free survival compared to conventional treatment, Nonetheless, most patients eventually succumb due to disease progression. Allogeneic transplantation may induce long-term remissions and even cure, but is hampered by a high transplantation-related mortality (TRM), Currently, efforts are made to reduce this TRM and to evaluate the graft-versus-myeloma effect.

引用

页码：S25 / S26

页数：2

共 12 条

[1]

ALEXANIAN R, 1994, NEW ENGL J MED, V330, P484

[2] A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma [J].

Attal, M ;

Harousseau, JL ;

Stoppa, AM ;

Sotto, JJ ;

Fuzibet, JG ;

Rossi, JF ;

Casassus, P ;

Maisonneuve, H ;

Facon, T ;

Ifrah, N ;

Payen, C ;

Bataille, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (02) :91-97

[3] Total therapy with tandem transplants for newly diagnosed multiple myeloma [J].

Barlogie, B ;

Jagannath, S ;

Desikan, KR ;

Mattox, S ;

Vesole, D ;

Siegel, D ;

Tricot, G ;

Munshi, N ;

Fassas, A ;

Singhal, S ;

Mehta, J ;

Anaissie, E ;

Dhodapkar, D ;

Naucke, S ;

Cromer, J ;

Sawyer, J ;

Epstein, J ;

Spoon, D ;

Ayers, D ;

Cheson, B ;

Crowley, J .

BLOOD, 1999, 93 (01) :55-65

[4]

GAHRTON G, 1999, 7 INT MULT MYEL WORK, P54

[5] High-dose therapy with peripheral blood progenitor cell transplantation in multiple myeloma [J].

Goldschmidt, H ;

Hegenbart, U ;

Wallmeier, M ;

Hohaus, S ;

Engenhart, R ;

Wannenmacher, M ;

Haas, R .

ANNALS OF ONCOLOGY, 1997, 8 (03) :243-246

[6]

GOLDSCHMIDT H, IN PRESS BONE MARROW

[7]

HAROUSSEAU JL, 1999, TRENDS ONCO HAEMATOL, V7, P33

[8]

LOCKHORST HM, 1997, BLOOD, V90, P4206

[9] Graft-versus-myeloma [J].

Mehta, J ;

Singhal, S .

BONE MARROW TRANSPLANTATION, 1998, 22 (09) :835-843

[10]

RUSSEL NH, 1999, 7 INT MULT MYEL WORK, P58

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