Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A Critical Review

被引：13

作者：

Zhang, Wenchao ^{[1
]}

Krafft, Paul R. ^{[2
]}

Wang, Tianlong ^{[3
]}

Zhang, John H. ^{[4
,5
]}

Li, Li ^{[6
]}

Tang, Jiping ^{[4
]}

机构：

[1] Beijing Jishuitan Hosp, Dept Anesthesiol, Beijing, Peoples R China

[2] Univ S Florida, Dept Neurol Surg & Brain Repair, Morsani Coll Med, Tampa, FL USA

[3] Capital Med Univ, Xuanwu Hosp, Dept Anesthesiol, 45 Chang Chun St, Beijing, Peoples R China

[4] Loma Linda Univ, Sch Med, Dept Physiol & Pharmacol, Loma Linda, CA 92350 USA

[5] Loma Linda Univ, Sch Med, Dept Anesthesiol, Loma Linda, CA 92350 USA

[6] Capital Med Univ, Beijing Friendship Hosp, Dept Anesthesiol, Beijing, Peoples R China

来源：

CELL TRANSPLANTATION | 2019年 / 28卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Ganglioside GM1; monosialotetrahexosylganglioside; stroke; AMINO-ACID RECEPTORS; BRAIN-INJURY; RAT MODEL; DISEASE; CELLS; NEUROTOXICITY; STRESS; REPAIR;

D O I：

10.1177/0963689718822782

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage; however, its clinical efficacy in patients with ischemic stroke is still uncertain. This review examines the recent knowledge of the neuroprotective properties of GM1 in ischemic stroke, collected in the past two decades. We conclude that GM1 may have potential for stroke treatment, although we need to be cautious in respect of its complications.

引用

页码：657 / 661

页数：5

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