Vestibular Function and Vertigo Control after Intratympanic Gentamicin for Meniere's Disease

被引：32
作者：
Nguyen, Kimanh D. [1 ]
Minor, Lloyd B. [1 ,2 ,3 ]
Della Santina, Charles C. [1 ,2 ]
Carey, John P. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21287 USA
来源：
AUDIOLOGY AND NEURO-OTOLOGY | 2009年 / 14卷 / 06期
关键词：
Meniere's disease; Gentamicin; Angular vestibulo-ocular reflex; Caloric unilateral weakness; Vertigo; COCHLEAR IMPLANTATION; ENDOLYMPHATIC HYDROPS; HEAD; STIMULATION; THERAPY;
D O I：
10.1159/000241893
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
The aim of this study was to correlate long-term vertigo control with reduction in vestibular function after intratympanic (IT) gentamicin therapy for unilateral Meniere's disease. IT gentamicin injections were given as needed to control vertigo attacks. Vertigo frequency and changes in angular vestibulo-ocular reflex (AVOR) gain (measured using magnetic search coils and manual head thrusts) and caloric weakness were assessed before and after treatment. Better vertigo control after treatment was found with >= 60% reduction in quantitative ipsilateral horizontal semicircular canal AVOR gain from pre-treatment values and/or with caloric unilateral weakness (UW) >= 50%. However, no correlations were found between the continuous variables of vertigo control and either gain or gain recovery, nor between gain and UW because of the large variability in vertigo control in subjects with lesser reductions in these measures. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：361 / 372
页数：12
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