Strength in Numbers: Visualizing CTL-Mediated Killing In Vivo

被引：5

作者：

Nolz, Jeffrey C. ^{[1
]}

Hill, Ann B. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97239 USA

来源：

IMMUNITY | 2016年 / 44卷 / 02期

关键词：

CYTOTOXIC T-LYMPHOCYTES; CELLS;

D O I：

10.1016/j.immuni.2016.01.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic CD8(+) T lymphocytes (CTLs) have long been believed to be extremely efficient killers. Forster and colleagues (Halle et al., 2016) used in vivo imaging to tell a different story, in which each CTL killed only 2-16 targets a day, and several CTLs per target were needed to get the job done.

引用

页码：207 / 208

页数：2

共 7 条

[1] Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus [J].

Bartholdy, C ;

Christensen, JP ;

Wodarz, D ;

Thomsen, AR .

JOURNAL OF VIROLOGY, 2000, 74 (22) :10304-10311

[2] Anatomically Restricted Synergistic Antiviral Activities of Innate and Adaptive Immune Cells in the Skin [J].

Hickman, Heather D. ;

Reynoso, Glennys V. ;

Ngudiankama, Barbara F. ;

Rubin, Erica J. ;

Magadan, Javier G. ;

Cush, Stephanie S. ;

Gibbs, James ;

Molon, Barbara ;

Bronte, Vincenzo ;

Bennink, Jack R. ;

Yewdell, Jonathan W. .

CELL HOST & MICROBE, 2013, 13 (02) :155-168

[3] Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues [J].

Holtappels, R ;

Podlech, J ;

Pahl-Seibert, MF ;

Jülch, M ;

Thomas, D ;

Simon, CO ;

Wagner, M ;

Reddehase, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (01) :131-136

[4] SERIAL KILLING BY CYTOTOXIC T-LYMPHOCYTES - T-CELL RECEPTOR TRIGGERS DEGRANULATION, RE-FILLING OF THE LYTIC GRANULES AND SECRETION OF LYTIC PROTEINS VIA A NON-GRANULE PATHWAY [J].

ISAAZ, S ;

BAETZ, K ;

OLSEN, K ;

PODACK, E ;

GRIFFITHS, GM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (04) :1071-1079

[5] Coordinated function of murine cytomegalovirus genes completely inhibits CTL lysis [J].

Pinto, Amelia K. ;

Munks, Michael W. ;

Koszinowski, Ulrich H. ;

Hill, Ann B. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (05) :3225-3234

[6] T cell killing does not require the formation of a stable mature immunological synapse [J].

Purbhoo, MA ;

Irvine, DJ ;

Huppa, JB ;

Davis, MM .

NATURE IMMUNOLOGY, 2004, 5 (05) :524-530

[7] Estimation of the rate of killing by cytotoxic T lymphocytes in vivo [J].

Regoes, Roland R. ;

Barber, Daniel L. ;

Ahmed, Rafi ;

Antia, Rustom .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (05) :1599-1603

← 1 →