Nitric oxide signalling in the brain and its control of bodily functions

被引：57
作者：
Chachlak, Konstantina [1 ,2 ,3 ,4 ]
Prevot, Vincent [1 ,2 ,3 ]
机构：
[1] INSERM, Lab Dev & Plastic Neuroendocrine, Jean Pierre Aubert Res Ctr, UMR S 1172, Lille, France
[2] Univ Lille, Sch Med, Lille, France
[3] CHU Lille, FHU Days Hlth 1000, Lille, France
[4] CHU Vaudois, Serv Endocrinol Diabetol & Metab, Lausanne, Switzerland
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2020年 / 177卷 / 24期
关键词：
PROTEIN S-NITROSYLATION; SOLUBLE GUANYLATE-CYCLASE; NUCLEOTIDE-GATED CHANNEL; ARGININE METHYL-ESTER; GENE-RELATED PEPTIDE; RAT MEDIAN-EMINENCE; SYNTHASE IN-VITRO; CONCISE GUIDE; ENDOTHELIAL-CELLS; RELAXING FACTOR;
D O I：
10.1111/bph.14800
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival of mammalian species by endowing brain neuronal networks with the ability to make continual adjustments to function in response to moment-to-moment changes in physiological input. Here, we summarize the progress in the field and argue that NO-synthetizing neurons and NO signalling in the brain provide a core hub for integrating sensory- and homeostatic-related cues, control key bodily functions, and provide a potential target for new therapeutic opportunities against several neuroendocrine and behavioural abnormalities.
引用
收藏
页码：5437 / 5458
页数：22
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