PAM variants were associated with type 2 diabetes mellitus risk in the Chinese population

被引：3
作者：
Sheng, Binwu [1 ]
Wei, Huiyi [2 ]
Li, Zhiying [3 ]
Wei, Haoyang [4 ]
Zhao, Qingbin [3 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Geriatr Surg, Xian 710061, Shaanxi, Peoples R China
[2] Yanan Univ, Med Sch, Yanan 710000, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Geratol, Xian 710061, Shaanxi, Peoples R China
[4] Xuzhou Med Univ, Dept Clin Med, Xuzhou 221004, Jiangsu, Peoples R China
来源：
FUNCTIONAL & INTEGRATIVE GENOMICS | 2022年 / 22卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Type 2 diabetes mellitus; The Chinese population; PAM; Variants; LOW-FREQUENCY; CELL; PREVALENCE; LEADS;
D O I：
10.1007/s10142-022-00840-0
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
This study aimed to assess the association between PAM single-nucleotide polymorphisms (SNPs) and T2DM risk in the Chinese population. We performed the genotype of PAM SNPs using Agena MassARRAY in 1002 subjects. The effect of PAM polymorphisms on T2DM occurrence was evaluated by logistic regression analysis. False-positive report probability (FPRP) was utilized to assess the noteworthiness of the significant results. This study showed that PAM rs406761, rs17154889, and rs6889592 were related to an increased risk of T2DM. The similar results were also in subjects with <= 60 years. Rs2431320 and rs406761 were related to an increased risk of T2DM in males, and rs6889592 was only found to be associated with T2DM risk in females. Rs2431320 and rs406761 increased T2DM risk in people with BMI > 24, and rs6889592 and rs26431 significantly correlated with T2DM risk in people with BMI <= 24. By comparing patients with no retinopathy with controls, the correlation between PAM rs406761 and rs17154889 and T2DM risk was observed. The significant association between T2DM risk and PAM SNPs was remarkable by FPRP values. PAM SNPs were correlated with T2DM risk in the Chinese population, illustrating the importance of PAM SNPs in the pathogenesis of T2DM.
引用
收藏
页码：525 / 535
页数：11
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