4-aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

被引：23

作者：

Pinard, E ^{[1
]}

Alanine, A

Bourson, A

Büttelmann, B

Heitz, MP

Mutel, V

Gill, R

Trube, G

Wyler, R

机构：

[1] F Hoffmann La Roche Ltd, Div Pharma, Discovery Chem, CH-4070 Basel, Switzerland

[2] F Hoffmann La Roche Ltd, Div Pharma, Preclin CNS Res, CH-4070 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(02)00470-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2615 / 2619

页数：5

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