State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes

被引：13

作者：

Bozdag, Murat ^{[1
]}

Altamimi, Abdulmalik Saleh Alfawaz ^{[2
]}

Vullo, Daniela ^{[1
]}

Supuran, Claudiu T. ^{[1
]}

Carta, Fabrizio ^{[1
]}

机构：

[1] Univ Firenze, NEUROFARBA Dept, Sez Sci Farmaceut & Nutraceut, Via Ugo Schiff 6, I-50019 Florence, Italy

[2] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, POB 173, Alkharj 11942, Saudi Arabia

来源：

CURRENT MEDICINAL CHEMISTRY | 2019年 / 26卷 / 15期

关键词：

metalloenzymes; carbonic anhydrases; enzyme activators; enzyme inhibitors; tumors; reumathoid arthritis; glaucoma; ISOZYME-II; ACTIVE-SITE; DRUG DISCOVERY; ISOFORMS-I; CRYSTALLOGRAPHIC ANALYSIS; EMERGING DRUGS; L-HISTIDINE; INHIBITORS; ACTIVATORS; VII;

D O I：

10.2174/0929867325666180622120625

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current review is intended to highlight recent advances in the search of new and effective modulators of the metalloenzymes Carbonic Anhydrases (CAs, EC 4.2.1.1) expressed in humans (h). CAs reversibly catalyze the CO2 hydration reaction, which is of crucial importance in the regulation of a plethora of fundamental processes at cellular level as well as in complex organisms. The first section of this review will be dedicated to compounds acting as activators of the hCAs (CAAs) and their promising effects on central nervous system affecting pathologies mainly characterized from memory and learning impairments. The second part will focus on the emerging chemical classes acting as hCA inhibitors (CAIs) and their potential use for the treatment of diseases.

引用

页码：2558 / 2573

页数：16

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