A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

被引：49
作者：
Filipski, Kevin J.
Kohrt, Jeffrey T.
Casimiro-Garcia, Agustin
Van Huis, Chad A.
Dudley, Danette A.
Cody, Wayne L.
Bigge, Christopher F.
Desiraju, Shrilakshmi
Sun, Shaoyi
Maiti, Samarendra N.
Jaber, Mohamad R.
Edmunds, Jeremy J.
机构：
[1] Pfizer Global Res & Dev, Michigan Labs, Ann Arbor, MI 48105 USA
[2] Naeja Pharmaceut Inc, Edmonton, AB T6E 5V2, Canada
[3] PharmAgra Labs Inc, Brevard, NC 28712 USA
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 44期
关键词：
D O I：
10.1016/j.tetlet.2006.08.112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A robust method has been developed to couple a wide variety of pyridin-2-ones and aryl halides. This C-N bond forming reaction makes use of catalytic copper(I) iodide and the ligand 8-hydroxyquinoline. These conditions tolerate a wide degree of functionality on both the aryl halide and pyridin-2-one reactants and have resulted in numerous examples being synthesized. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7677 / 7680
页数：4
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