A Complete Pathological Response to Pembrolizumab following ex vivo Liver Resection in a Patient with Colorectal Liver Metastases

被引：15

作者：

Baimas-George, Maria ^{[1
]}

Baker, Erin ^{[2
]}

Kamionek, Michal ^{[3
]}

Salmon, J. Stuart ^{[4
]}

Sastry, Amit ^{[2
]}

Levi, David ^{[5
]}

Vrochides, Dionisios ^{[2
]}

机构：

[1] Carolinas Healthcare Syst, Dept Gen Surg, Carolinas Med Ctr, Charlotte, NC USA

[2] Carolinas Healthcare Syst, Dept Hepatopancreatobiliary Surg, Carolinas Med Ctr, Charlotte, NC USA

[3] Carolinas Healthcare Syst, Dept Pathol, Carolinas Med Ctr, Charlotte, NC USA

[4] Carolinas Healthcare Syst, Dept Med Oncol, Carolinas Med Ctr, Charlotte, NC USA

[5] Carolinas Healthcare Syst, Dept Transplant Surg, Carolinas Med Ctr, Charlotte, NC USA

来源：

CHEMOTHERAPY | 2018年 / 63卷 / 02期

关键词：

Cancer immunotherapy; Chemotherapy; Colorectal cancer; Hepatic metastases; Pathologically complete response; Pembrolizumab; HEPATIC RESECTION; MARGIN STATUS; CANCER; CHEMOTHERAPY; SURVIVAL; THERAPY; TUMORS; RECURRENCE; CETUXIMAB; ANTIBODY;

D O I：

10.1159/000487814

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advances in the systemic treatment of stage IV colorectal cancer with liver metastases has offered improved survival rates for patients who otherwise face a dismal prognosis. However, a pathologically complete response (PCR) to chemotherapy for colorectal liver metastases is still rare, and its significance is not fully understood. In this case report, we describe a patient who achieved PCR after neoadjuvant immunotherapy with pembrolizumab and a left hepatectomy using an ex vivo resection technique. (c) 2018 S. Karger AG, Basel

引用

页码：90 / 94

页数：5

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