Long term follow-up and outcomes in adult patients with thalamic gliomas

被引：6
作者：
Li, Zhiqi [1 ]
Wu, Hanfeng [1 ,2 ]
Wu, Biwu [1 ]
Lyu, Jiaying [4 ]
Liu, Yikui [3 ]
Tang, Chao [1 ]
Hua, Wei [1 ]
Hu, Shukun [1 ]
Wang, Yang [1 ,2 ]
Zhang, Yi [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Neurosurg, 12 Wulumuqi Middle Rd, Shanghai, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Radiat Oncol, Shanghai, Peoples R China
[3] Fudan Univ, Huadong Hosp, Dept Neurosurg, Shanghai, Peoples R China
[4] Fudan Univ, Sch Publ Hlth, Dept Biostat, Shanghai, Peoples R China
来源：
CLINICAL NEUROLOGY AND NEUROSURGERY | 2020年 / 195卷
关键词：
Thalamic tumor; Glioma; Adult; Treatment; VOLUMETRIC RESECTION; PROGNOSTIC-FACTORS; TUMORS; CHILDREN; ASTROCYTOMAS; BIOPSY;
D O I：
10.1016/j.clineuro.2020.105888
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objectives: To investigate the optimal treatment and prognosis of thalamic glioma in adult patients. Patients and methods: We retrospectively analyzed the adult patients with thalamic glioma admitted to our hospital from May 2005 to September 2016. Patients were divided into two groups according to their treatment: surgery-based combined treatment and intensity modulated radiation therapy (IMRT)-based treatment. Univariate chi-square test and multivariate logistic regression were used to identify independent factors for the treatment modality. A log-rank test, adjusting for propensity score, was used to compare the overall survival (OS) and progression-free survival (PFS) of patients between the two groups. Results: Fifty-eight adult patients with thalamic gliomas were included in the analysis. Of them, 31 were treated with surgery-based treatment, and 27 were treated with IMRT-based treatment. The overall survival (OS) and progression-free survival (PFS) of patients between the two groups were not significantly different (median OS 16.0 (range 1.0-163.0) months vs. 10.0 (range 1.0-118.0) months, p = 0.344 and median PFS 10.0 (range 1.0-163.0) months vs. 6.0 (range 1.0-118.0) months, p = 0.464, respectively) even after adjusting for potential confounding factors. Conclusions: The OS and PFS of adult patients with thalamic glioma were not significantly different between patients in the surgical group and in the IMRT group. IMRT might be an acceptable alternative to surgery for adult patients with unresectable thalamic glioma.
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页数：7
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