Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

被引：18

作者：

Chen, Tong ^{[1
,2
]}

Xie, Ni ^{[3
]}

Viglianti, Lucia ^{[3
]}

Zhou, Yabin ^{[1
,4
]}

Tan, Hui ^{[5
]}

Tang, Ben Zhong ^{[3
]}

Tang, Youhong ^{[1
]}

机构：

[1] Flinders Univ S Australia, Sch Comp Sci Engn & Math, Ctr NanoScale Sci & Technol, Bedford Pk, SA 5042, Australia

[2] Flinders Univ S Australia, Sch Med, Dept Med Biochem, Bedford Pk, SA 5042, Australia

[3] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[4] Flinders Univ S Australia, Flinders Ctr Innovat Canc, Dept Gastroenterol & Hepatol, Bedford Pk, SA 5042, Australia

[5] Shenzhen Univ, Shenzhen Key Lab Neurosurg, Affiliated Hosp 1, Shenzhen 518035, Peoples R China

来源：

FARADAY DISCUSSIONS | 2017年 / 196卷

关键词：

HUMAN SERUM-ALBUMIN; CONFORMATIONAL TRANSITIONS; CREATININE; URINE; PROTEINURIA; ISSUES;

D O I：

10.1039/c6fd00153j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.

引用

页码：351 / 362

页数：12

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